GMS 6552 EXAM 2 QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST UPDATE
0 view 0 purchase
Course
GMS6552
Institution
GMS6552
GMS 6552 EXAM 2 QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST UPDATE
MODULE 5
An oncogene is defined as
a gene that causes or contributes to the development of cancer
What are the two types of evidence for oncogenic behavior?
In vivo
In vitro
What are the 4 criteria for In ...
gms 6552 exam 2 questions and answers with complet
Written for
GMS6552
All documents for this subject (12)
Seller
Follow
NurseAdvocate
Reviews received
Content preview
GMS 6552 EXAM 2 QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS VERIFIED LATEST UPDATE
MODULE 5
An oncogene is defined as
a gene that causes or contributes to the development of cancer
What are the two types of evidence for oncogenic behavior?
In vivo
In vitro
What are the 4 criteria for In vivo oncogenic behavior
Cause cancer when activated in a transgenic animal
Render nontumorigenic cells tumorigenic
Knock down or knock out in tumorigenic cells renders the cells nontumorigenic
Activation/overexpression of the oncogene is strongly correlated with human cancer
What are the 3 criteria for In vitro oncogenic behavior
Causes anchorage-independent growth in soft agar (protection from anoikis)
Causes focus formation (loss of contact inhibition)
Renders cells growth factor independent
What is an example of a GTPase that plays a biochemical role in oncogenes.
Ras
What is an example of a Protein Kinases that plays a biochemical role in
oncogenes.
, Raf, Akt, BCR-ABL, Cdk4, Src
What is an example of a Lipid Kinases that plays a biochemical role in
oncogenes.
PI3-Kinase
What is an example of a Transcription factors that plays a biochemical role in
oncogenes.
Myc, Fos, Jun, E2F1, ....
What is an example of a Binding and inactivating apoptotic proteins that plays a
biochemical role in oncogenes.
BCL2
What is an example of a Protein Kinase Regulatory Subunits that plays a
biochemical role in oncogenes.
Cyclins A, E, and D
What is an example of a Transcriptional coactivators that plays a biochemical role
in oncogenes.
ß-Catenin, YAP, TAZ
Five Ways to Activate Oncogenes
1. Mutation of genes to make it overactive.
2. Amplification of a normal gene
3. Chromosomal Rearrangement
4. Promoter/enhancer insertion
5. Hypomethylation of oncogene
What are some examples of Chromosome Rearrangement? (2)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller NurseAdvocate. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.99. You're not tied to anything after your purchase.
