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Nagelhout-Pharm 2-Exam 1 UPDATED Questions and CORRECT Answers

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Nagelhout-Pharm 2-Exam 1 UPDATED Questions and CORRECT Answers Ultra short acting neuromuscular blocker (Length of duration) - CORRECT ANSWER -Succinylcholine (5 - 15 minutes) Depolarizing NMB - CORRECT ANSWER -Succinylcholine

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  • November 24, 2024
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  • 2024/2025
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Nagelhout-Pharm 2-Exam 1 UPDATED
Questions and CORRECT Answers
Ultra short acting neuromuscular blocker

(Length of duration) - CORRECT ANSWER -Succinylcholine
(5 - 15 minutes)


Depolarizing NMB - CORRECT ANSWER -Succinylcholine


Intermediate Acting Nondepolarizing NMBs (4)

(Length of duration) - CORRECT ANSWER -Atracurium
Cisatracurium
Vecuronium
Rocuromium
(30-60 minutes)


Long Acting Nondepolarizing NMB

(Length of duration) - CORRECT ANSWER -Pancuronium
60-90 minutes


Short Acting Nondepolarizing NMBs

(Length of duration) - CORRECT ANSWER -None
(20-30 minutes)


NMB Reversal Agents (3) - CORRECT ANSWER -Neostigmine
Edrophonium
Sugammadex (not approved by FDA)

,NMBs work at ____ receptors - CORRECT ANSWER -Nicotinic Cholinergic (sub-m)



Neurotransmitter of the NM junction - CORRECT ANSWER -acetylcholine



Breaks down acetylcholine at the NM synapse/junction - CORRECT ANSWER -
acetylcholinesterase


Non-depolarizing agents are: agonists or antagonists - CORRECT ANSWER -Antagonist



Depolarizing agents act as: agonist or antagonist?? - CORRECT ANSWER -Agonist then
antagonist


Onset time definition - CORRECT ANSWER -time from drug administration to
maximum effect


Clinical duration definition - CORRECT ANSWER -time from drug administration to
25% recovery of twitch response


Total duration of action definition - CORRECT ANSWER -time from drug administration
to 90% recovery of twitch response (point at which pt is recovered)


Recovery index definition - CORRECT ANSWER -time from 25% to 75% recovery of
twitch response (how fast?)


Train of Four Index - CORRECT ANSWER -4th twitch of TOF/1st twitch of TOF



Muscle stimulated by ulnar nerve in TOF - CORRECT ANSWER -Adductor pollicis



Best nerve/muscle to measure onset of NMB - CORRECT ANSWER -Facial Nerve

, Orbicularis Oculi (Corrugator supercilii = best)
(reflects diaphragm blockade)


Best nerve/muscle to measure emersion from NMB - CORRECT ANSWER -Ulnar Nerve
Adductor Pollicis


Single Twitch Test - CORRECT ANSWER -1.0 Hz
Single stimulus
Compares pre (baseline) and post NMB hand twitch


Train of Four Test - CORRECT ANSWER -4 - 2 Hz twitches
Compares 4th twitch to 1st twitch (fade)
Reflects 70-100% blockade


Double Burst Simulation (DBS) Test - CORRECT ANSWER -2 - 50 Hz twitches
0.75 seconds apart
Compares 2 twitches to monitor for fade


Tetanus Test - CORRECT ANSWER -100 Hz twitch for 5 seconds
Painful


Posttetanic Count Test - CORRECT ANSWER -50 Hz stimulus for 5 sec → 3 sec pause
→ 1 Hz single twitch every second
Only used when patient is 100% paralyzed
More post-tetanic twitches = closer to recovery


Sequence of muscle paralysis - CORRECT ANSWER -1. Eyelids (Protective muscles of
pharynx)

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