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GMS6530: DIURETICS AND ANTIHYPERTENSIVES EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED $11.49
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GMS6530: DIURETICS AND ANTIHYPERTENSIVES EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED

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GMS6530: DIURETICS AND ANTIHYPERTENSIVES EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED general diuretic uses -edema (accumulation of fluid in body in cardiovascular, renal, endocrine diseases) -hypertension -other diseases (described later) T/F: GFR is 125 ml/min and > 124 ml/...

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  • November 26, 2024
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  • 2024/2025
  • Exam (elaborations)
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GMS6530: DIURETICS AND ANTIHYPERTENSIVES EXAM

QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS

VERIFIED

general diuretic uses

-edema (accumulation of fluid in body in cardiovascular, renal, endocrine diseases)

-hypertension

-other diseases (described later)

T/F: GFR is 125 ml/min and > 124 ml/min is reabsorbed

True

T/F: the nephron is the functional unit of the kidney

True

general properties of diuretics

1. have direct action on the kidney

2. decrease Na+ reabsorption in the renal tubules

3. various diuretics: a. Act at different sites in the renal tubule, b. differ in their intensity

of action (efficacy), c. differ in their undesirable (and desirable effects)

the renal tubule is a single layer of __________ cells.

epithelial

T/F: unidirectional transport of Na+ is dependent on the polarity of renal tubular

cells

True

T/F: Na+ transport proteins are present ONLY in luminal or apical membrane

, True

T/F: Na+-K+-ATPase (Na+ pump) is present only in the basal and lateral

membrane

True

Two membranes are separated by __________ junctions.

tight

proximal convuluted tubule (PCT)

-around 50% of filtered Na+ and water are reabsorbed

-carbonic anhydrase inhibitor diuretics = acetazolamide = inhibits NaHCO3 reabsorption

Acetazolamide

-carbonic anhydrase inhibitor diuretic

-inhibits NaHCO3 reabsorption

-indirectly inhibits the sodium proton exchanger

-occurs in PCT

-major side effect is metabolic acidosis (more basic urine)

loop of henle

-around 35% of NaCl reabsorbed

-loop diuretics (furosemide) inhibit NaCl reabsorption in Thick Ascending Limb (TAL) of

Loop of Henle

Furosemide

-lasix

-occurs in TAL of LOH

-blocks Na+ reabsorption by binding to NKCC2 (sodium chloride potassium

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