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Samenvatting Farmacotherapie en Farmaceutische zorg 1, word doc.

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Deze samenvatting bundelt de essentiele zaken van het eerste master vak farmacotherapie en farmaceutische zorg 1. Dit vak wordt in het eerste masterjaar van de richting farmaceutische wetenschappen gedoceerd. Het bevat eerste uitgiftebegeleidingen, doorverwijscriteria, interacties en alle andere ...

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  • December 1, 2024
  • 191
  • 2023/2024
  • Summary
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Farmaceutische zorg en farmacotherapie 1
2023 – 2024


Inhoudsopgave
1. Algemene inleiding.................................................................................................................................... 4
Wat is farmacotherapie?..................................................................................................................................4
Wat is farmaceutische zorg?...........................................................................................................................11
Zelfzorgadvies.................................................................................................................................................13
Vermijden van medicatiefouten – medicatiebewaking..................................................................................15

2. Therapietrouw......................................................................................................................................... 15
Types niet-therapietrouw...............................................................................................................................16

3. Interacties en geneesmiddelen................................................................................................................. 17
Interactiemechanismen..................................................................................................................................17
Gevolgen van interacties................................................................................................................................18
Interacties afhandelen....................................................................................................................................18
Arts contacteren.............................................................................................................................................20

4. Farmacokinetische interacties.................................................................................................................. 20
Interacties ter hoogte van de absorptie.........................................................................................................20
Interacties ter hoogte van de distributie........................................................................................................20
Interacties ter hoogte van de metabolisatie..................................................................................................21
Interacties ter hoogte van de excretie............................................................................................................23
Interacties ter hoogte van de PgP’s................................................................................................................23

5. Farmacodynamische interacties................................................................................................................ 23
Hyperkaliëmie.................................................................................................................................................23
Bloedingsrisico................................................................................................................................................24
Serotonine syndroom.....................................................................................................................................26
QT interval......................................................................................................................................................26
Farmacologische antagonismen.....................................................................................................................27

6. Farmacotherapie bij speciale populaties................................................................................................... 28
Zwangere vrouwen.........................................................................................................................................28
Vrouwen met kinderwens..............................................................................................................................29
Vrouwen die borstvoeding geven...................................................................................................................29
Kinderen.........................................................................................................................................................30
Ouderen..........................................................................................................................................................31

1. Cardiovasculair risicobeheer..................................................................................................................... 32
Apparently healthy people – risicobeheer.....................................................................................................32
Patiënten met vastgesteld ASCVD..................................................................................................................33
Specifieke risico-condities..............................................................................................................................33
Risicobeheer: aanpak risicofactoren..............................................................................................................34

2. Diuretica.................................................................................................................................................. 38

3. ß-blokkers................................................................................................................................................ 41

4. Calciumantagonisten................................................................................................................................ 47

5. ACE-inhibitoren en sartanen..................................................................................................................... 48
ACE-inhibitoren...............................................................................................................................................48

,Farmaceutische zorg en farmacotherapie 1
2023 – 2024

Sartanen..........................................................................................................................................................53

6. ARNI: sacubitril/valsartan complex........................................................................................................... 53

7. Anti-artimica............................................................................................................................................ 54

8. Nitraten................................................................................................................................................... 57

9. Hypolipemiërende middelen.................................................................................................................... 59
Statines...........................................................................................................................................................59
PCSK9-inhibitoren...........................................................................................................................................64

10. Antitrombotica....................................................................................................................................... 66
Anti-aggregantia.............................................................................................................................................68
Anticoagulantia...............................................................................................................................................70
Aandachtspunten antitrombotica..................................................................................................................75

11. Digoxine................................................................................................................................................. 76

1. Medicatiebegeleiding bij PPI’s.................................................................................................................. 77
Farmacologie van de PPI’s..............................................................................................................................77
Uitgiftebegeleiding.........................................................................................................................................77
Problematiek rond onnodig PPI gebruik.........................................................................................................78

2. Medicatiebewaking bij PPI’s..................................................................................................................... 80
CYP2C19..........................................................................................................................................................80
GM waarvan BB afhankelijk is van de gastro-intestinale pH..........................................................................80

3. Medicatiebegeleiding bij aminosalicylaten............................................................................................... 80

4. Maagklachten bij NSAID-gebruikers.......................................................................................................... 81

5. Zelfzorg.................................................................................................................................................... 82
Refluxklachten & brandend maagzuur...........................................................................................................82
Dyspepsie........................................................................................................................................................85
Nausea & braken............................................................................................................................................85
Diarree............................................................................................................................................................87
Constipatie......................................................................................................................................................90
Proctologische aandoeningen, Aambeien en anale fissuren.........................................................................94
Diarree/GI klachten bij colchicine toxiciteit...................................................................................................96
Preventie opiaat – obstipatie..........................................................................................................................96

1. Astma vs COPD......................................................................................................................................... 97

2. Therapeutische klassen van inhalatiemedicatie........................................................................................98
ß2 agonisten (BA)...........................................................................................................................................98
Inhalatiecorticosteroïden...............................................................................................................................98
ICS + ß2 combinatie........................................................................................................................................98
Anticholinergica: muscarine antagonisten (MA)............................................................................................99
SABA + SAMA combinatie...............................................................................................................................99
LABA + LAMA combinatie...............................................................................................................................99
ICS + LABA + LAMA: single inhaler triple therapy...........................................................................................99

3. Behandelingsplan ASTMA......................................................................................................................... 99

,Farmaceutische zorg en farmacotherapie 1
2023 – 2024

Monoklonale antilichamen in astma behandeling.......................................................................................100

4. Behandelingsplan COPD......................................................................................................................... 100
Behandeling GOLD groep B..........................................................................................................................100
Behandeling GOLD groep D..........................................................................................................................100
Behandeling acute exacerbatie COPD..........................................................................................................100

5. Medicatiebegeleiding............................................................................................................................. 101
Astma............................................................................................................................................................101
COPD.............................................................................................................................................................101

6. Medicatiebewaking................................................................................................................................ 107
Geneesmiddelinteracties..............................................................................................................................107
Contra-indicaties...........................................................................................................................................108
Zwangerschap en borstvoeding....................................................................................................................109
Andere aandachtspunten.............................................................................................................................109

7. Zelfzorg bij astma en COPD patiënten..................................................................................................... 110
Astma............................................................................................................................................................110
COPD.............................................................................................................................................................110
Insuline – begeleiding...................................................................................................................................111
Orale antidiabetica – begeleiding.................................................................................................................114
Pre-operatief beleid bij antidiabetica...........................................................................................................119
Extra informatie............................................................................................................................................119
Medicatiebewaking......................................................................................................................................120
Zelfzorg bij diabetici......................................................................................................................................122
Medicatiebegeleiding...................................................................................................................................125
Medicatiebewaking......................................................................................................................................126
Medicatiebegeleiding...................................................................................................................................128
Medicatiebewaking......................................................................................................................................131

1. Homonale anticonceptie – indeling......................................................................................................... 132
Oestroprogestagene associaties...................................................................................................................132
Progestagenen..............................................................................................................................................133
IUD................................................................................................................................................................133
Andere..........................................................................................................................................................133

2. Menopauzale klachten........................................................................................................................... 133

3. Farmaceutische zorg bij anticonceptie en menopauzale klachten............................................................135
Medicatiebegeleiding...................................................................................................................................135
Medicatiebewaking......................................................................................................................................139
Noodanticonceptie.......................................................................................................................................140

4. Zelfzorg bij menstruatiepijn.................................................................................................................... 142
Niet medicamenteus advies.........................................................................................................................143
Medicamenteus advies.................................................................................................................................143

1. Urogenitale problemen.......................................................................................................................... 144
Blaasfunctiestoornissen................................................................................................................................144
Benigne prostaathypertrofie/mictieklachten bij mannen............................................................................145
Vaginale klachten..........................................................................................................................................147
Impotentie....................................................................................................................................................149

, Farmaceutische zorg en farmacotherapie 1
2023 – 2024

Bedplassen....................................................................................................................................................149

2. Farmacotherapie bij urineweginfecties (UWI)......................................................................................... 149
Acute cystitis/blaasontsteking......................................................................................................................150
Recidiverende cystitis...................................................................................................................................151
Acute pyelonefritis........................................................................................................................................151
Asymptomatische bacteriurie.......................................................................................................................153

1. Achtergrond........................................................................................................................................... 154
Types pijn......................................................................................................................................................154
Biopsychosociaal model...............................................................................................................................154
Behandeldoel................................................................................................................................................154

2. Behandeling van pijn.............................................................................................................................. 155
Niet medicamenteus....................................................................................................................................155
Medicamenteus............................................................................................................................................156
Cannabis/cannabinoïden..............................................................................................................................159
Opioïdencrisis in USA....................................................................................................................................159
Opioïdrotatie................................................................................................................................................160

3. Farmaceutische zorg bij pijn.................................................................................................................... 160
Paracetamol..................................................................................................................................................160
Opioïden.......................................................................................................................................................161

4. Farmaceutische zorg bij koorts................................................................................................................ 166
Achtergrond..................................................................................................................................................166
Niet-medicamenteus advies.........................................................................................................................167
Medicamenteus advies.................................................................................................................................167

1. Systemische NSAID’s............................................................................................................................... 170
Medicatiebegeleiding...................................................................................................................................171
Medicatiebewaking......................................................................................................................................177

2. Farmaceutische zorg bij osteoarticulaire aandoeningen..........................................................................178
Reumatoïde artritis.......................................................................................................................................178
Jicht...............................................................................................................................................................182
Artrose: slijtagereuma..................................................................................................................................184

3. Farmaceutische zorg bij osteoporose...................................................................................................... 186
Achtergond...................................................................................................................................................186
Behandeling osteoporose.............................................................................................................................186
Farmaceutische zorg bij osteoporose...........................................................................................................188

Hoofdstuk 1
1. Algemene inleiding
Wat is farmacotherapie?
Doel: optimale behandeling van patiënten met geneesmiddelen.

GM = essentiële tool om klachten of aandoeningen te behandelen of te
voorkomen.
 geneesmiddelengebruik, moet altijd rationeel gebeuren.

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