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BICH 431 FINAL EXAM QUESTIONS WITH LATEST UPDATE
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BICH 431 FINAL EXAM QUESTIONS WITH LATEST UPDATE
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BICH 431 FINAL EXAM QUESTIONSWITH LATEST UPDATE
Which of the following is NOT how nucleosome formation affects DNA?
A. regulates the rate of DNA replication in mitochondria
B. competes with transcription factor Sp1 to maintain transcriptional repression
C. compacts the DNA in the nucleus
D. alters access to DNA by enzymes
E. inhibits transcription by the inter-nucleosome connections mediated by histone tails -
Answer-A. regulates the rate of DNA replication in mitochondria
When turns are removed from a closed circular DNA, the DNA may become:
A. underwound, but this form is unstable and typically reverts to the relaxed state
B. underwound and supercoils will result
C. overwound and supercoils will result
D. overwound, but this form is unstable and typically reverst to the relaxed state
E. underwound or overwound depending on the sequence of the DNA - Answer-B.
underwound and supercoils will result
Which of the following is the best evidence that supercoiling is an intrinsic property of
double stranded DNA molecules?
A. None of these choices are correct
B. When two strands of an entwined rubber band are pulled apart they will twist into
supercoils
C. linear fragments of double-stranded DNA are not supercoiled
D. Purified plasmid DNAs are supercoiled even though all proteins are removed
E. stranded separation during transcription and replication introduces supercoiling -
Answer-D. Purified plasmid DNAs are supercoiled even though all proteins are removed
Which type of these protein components are often found in chromatin remodeling
complexes that increase transcription and included an ATPase subunit?
A. chromodomain proteins
B. chaperone proteins
C. bromodomain proteins
D. both bromodomain and chromodomain proteins - Answer-C. bromodomain proteins
The genomes of many organisms have been sequenced. What benefits or uses could
result from this information?
A. tracing evolutionary history and relationships or organisms
B. All of these choices are benefits of genome sequences
C. personalizing medicine based on individual genomic sequencing
D. identifying genes of agricultural import
E. elucidating genetic patterns of medical interest - Answer-B. All of these choices are
benefits of genome sequences
, Oswald Avery found that DNA was necessary and sufficient for bacterial transformation.
Which of the following experimental results support this statement (select all that
apply)?
A. DNA alone will cause bacterial transformation to occur
B. Protein alone will cause bacterial transformation to occur
C. Removal of DNA from virulent streptococcus pneumoniae cell extracts eliminated
transformation
D. Removal of RNA from virulent Streptococcus pneumoniae cell extracts eliminated
transformation - Answer-A. DNA alone will cause bacterial transformation to occur
C. Removal of DNA from virulent streptococcus pneumoniae cell extracts eliminated
transformation
If this table shows C/T. What organism has the Lowest Tm?
A. Avian bacillus (0.4)
B. Escherichia coli (0.95)
C. Hemophilus (0.54)
D. Serratia marcescens (0.7)
E. Bacillus schatz (0.6) - Answer-A. Avian bacillus (0.4)
The double helix of a relaxed closed-circular RNA molecule has one turn of the double
helix per ____ base pairs.
A. 1
B. 11
C. 8
D. 10.5
E. 7.5 - Answer-B. 11
Herpes simplex type 1 usually causes oral infection, including "cold sores." The length
of the viral double stranded DNA genome is approximately 150 kb long. What would be
the approximate length of this DNA?
A. 500 A
B. 50 A
C. 500 um
D. 50 um - Answer-B. 50 A
Through an electron microscope, chromatin will have the appearance of beads on a
string. What protein(s) will "tighten" the beads to create a pronounced zigzag
appearance ?
A. bromodomain proteins
B. NAP-1
C. Sp1
D. scaffolding proteins
E. H1 histone - Answer-E. H1 histone
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