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PHM 431 Exam 1 Questions with Complete Answers

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  • BIO 431

PHM 431 Exam 1 Questions with Complete Answers

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  • December 2, 2024
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  • Exam (elaborations)
  • Questions & answers
  • BIO 431
  • BIO 431
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PHM 431 Exam 1 Questions with
Complete Answers
What best describes drug tolerance? - Answer-reduction in the drug response after
repeated drug administration

What kind of drug is most likely to cross the blood brain barrier? - Answer-very
hydrophobic drug with a low molecular weight

Which of the following molecules protects against acetaminophen hepato (liver) toxicity?
- Answer-Glutathione

What set of drug properties is most likely to give this drug a high addiction liability? -
Answer-a non-polar dopamine agonist with a molecular weight of 300

Pharmacokinetic tolerance - Answer-Loss of sensitivity to the effects of drug due to
changes in the distribution or metabolism of that drug

What would you not find in a synaptic active zone? - Answer-golgi apparatus

What term belongs with myelin sheeth and Node of Ranvier? - Answer-saltatory
conduction

Phencyclidine (PCP) will disrupt signaling at synapses that use which of the following
neurotransmitters - Answer-Glutamate

G-protein coupled receptors are subject to internalization caused by what mechanism? -
Answer-Agonist induced phosphorylation of GRK

5-hydroxytryptamine is a precursor for the synthesis of what molecule? - Answer-
melatonin

Which of the following SNARE proteins is calcium sensor for neurotransmitter release
by nerve terminals? - Answer-synaptotagmin

The equilibrium dissociation constant for a drug is a measure of drug: - Answer-affinity

efficacy - Answer-measured by the maximum response route of drug adminstration

what is a disadvantage of the intravenous route of drug administration? - Answer-high
risk of exceeding the toxic drug level

, When an agonist binds to its receptor, the agonist causes a response in the target cell
but it also causes receptor internalization? This mechanism can explain: - Answer-cross
tolerance/receptor downregulation

Factors that contribute to drug addiction and continued drug use - Answer-drug
tolerance
drug dependence
drug withdrawal

The EC50 is a measure of drug: - Answer-potency

What brain area is not part of the mesolimbic dopamine system? - Answer-
hypothalamus

An inhibitor of the enzyme dopamine-beta-hydroxylase will reduce brain levels of which
of the following neurotransmitters? - Answer-norepinephrine
- dopamine is the precursor for norepinephrine synthesis catalyzed by dopamine-b-
hydroxylase

Charybdotoxin - Answer-blocks K+ channels which are required for the repolarization
phase of action potentials

GTP-gamma-S is a drug that irreversibly activates G-proteins. One effect of treating
neurons with this drug would be: - Answer-increased levels of intracellular cyclic 3', 5'
AMP

One consequence of "knockout" or deletion of the gene that encodes the enzyme
phenylethanolamine-N-methyl-transferase would be: - Answer-depletion of epinephrine
from the adrenal medulla

Drugs which inhibit acetylcholinesterase would enhance neurotransmission in which
brain region? - Answer-Septohippocampal neurons
- ACh is an important neurotransmitter in this brain area

Knockout of the gene that encodes the enzyme, monamine oxidase would result in
enhanced neurotransmission at which kind of synapse? - Answer-5-HT synapses
and
gamma-ammino-butyric acid (GABA)

Pargyline is a drug that inhibits the enzyme monoamine oxidase. This drug would be
expected to strength synaptic transmission at which kind of synapse? - Answer-
Norepinephrine synapses, dopamine and serotonin

Chloride - Answer-predominant intracellular anion

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