BIOL 4100 EXAM 5 QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED
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Course
BIOL4100
Institution
BIOL4100
BIOL 4100 EXAM 5 QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED
what goes into the cellular garbage systems?
misfolded, unused, turnover proteins; metabolic products; organelles
describe the cellular garbage system
substrate enters cells through endocytosis; either ubiquitin added from ...
E1+Ub+ATP yields E1/Ub+ AMP+Pi add E2; yields E1 and E2 bound to Ub; binds to E3
with bound substrate; ubiquitin binds to substrate on E3; substrate released from E3
and further ubiquitination
ubiquitin activating enzyme 1:
1. E1 activates the C-terminus of ubiquitin by forming an ____ _____ intermediate
2. catalytic ______ residue "attacks" the ubiquitin causing release of AMP and
formation of what?
3. reaction is ____ as another ubiquitin is adenylated and the charged ubiquitin is
transferred to an ___ forming another thioester bond
-extremely _______ enzyme--turnover rate is 1-2/second
acyl-adenylate, cysteine, formation of an E1 ubiquitin thioester intermediate, repeated,
E2, efficient
why does the E1 reaction have to be very efficient?is this reaction ATP
dependent? why?
because there aren't many E1s, yes, loosing double Pi with energy required to add Ub
ubiquitin conjugation enzyme E2:
1. carries activated ubiquitin for the E1 to the ____
2. each _____ ____ has a Cys residuce located in a shallow groove at its active
site which will form a thioester bond with the ubiquiting molecule being _______
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