3 HET ENDOCRIEN STELSEL
HOMEOSTASE VIA COMMUNICATIE TUSSEN CELLEN
Afgifte van chemische stoffen binden aan R (receptor) op specifieke doelcellen
Hormoonstelsel : aan het bloed , chemische stof = hormoon
Zenuwstelsel : bij een synaps , chemische stof = neurotransmitter
Hormoonstelsel = alle endocriene cellen + weefsels van het lichaam
Endocriene cellen = cellen die klierproducten aan de extracellulaire vloeistof afgeven
Regulering : hiërarchie
Niveau 1 : ‘master centra’ thv CZS : cortex, hypothalamus
(releasing + stimulating hormones)
Niveau 2 : ‘master klier’ hypofyse
Adenohypofyse = glandulotrope hormonen
Neurohypofyse = autonome hormonen rechtstreeks naar doelorgaan
(stimulating hormones) = -troop hormoon
Niveau 3 : endocriene klieren
(-hormoon, genoemd naar endocriene klier)
Niveau 4 : doelwitorganen
Voorbeeld
Niveau 1 : hypothalamus
(Thyroid Releasing Hormone)
Niveau 2 : adenohypofyse
(Thyroid Stimulating Hormone)
Niveau 3 : schildklier
(Thyroid hormoon = Thyroxine)
Niveau 4 : “alle cellen”
FUNCTIE VAN HORMOONSTELSEL : HOMEOSTASE (VIA COMMUNICATIE TUSSEN
CELLEN)
feedback
Indien voldoende eindproduct negatieve feedback : hogere centra (1 en 2) worden
geremd
Hoe wordt cortisol afgegeven
Niveau 1 : hypothalamus
CRH = cortisol releasing hormoon
Niveau 2 : adenohypofyse
ACTH = adrenocorticotroop hormoon
Niveau 3 : bijnierschors
cortisol
Niveau 4 : “alle cellen”
1
, BINDING VAN HORMONEN AAN RECEPTOREN
WAT ZIJN HORMONEN?
Hormonen = chemische boodschapperstoffen voor de regulatie van orgaanfuncties en
fysiologische processen (voor het handhaven van homeostase)
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