Summary
Allergology Summary
- Course
- Institution
Summary of the course “allergology” taught in bachelor 3 medicine
[Show more]
Seller
Follow
mh14
Content preview
INTRODUCTIEIMMUNE SYSTEM FUNCTION
• Defence
- pathogens, harmful agents, tumours, noxes
• Discrimination
- “SELF – NON-SELF” (TOLERANCE)
- Dangerous (danger signals)
- non-dangerous Innate immune response - adaptive immune response (lymphocytes)
➔ Humoral – cellular component
- Well-controlled (to avoid excessive activation)
HYPERSENSITIVITY = ALLERGY
• Allergy involves activation of adaptive immune system (with activation of specific T and B cells)
• Other mechanisms:
- Effector cell activation via other receptors
- Interference with enzymes: COX, ACEi
! bradikinine veroozaakt vasodilatatie & voor oedeem
1
, ! type IV bestaat uit a,b,c & d !
! type I & II zijn clinical diagnosis!
! rash is not a diagnosis!
2
,TIMING OF DHR
• Immediate DHR < 1h (<6)
- Urticaria / angioedema
- Respiratory
- Gastro-intestinal
- Cardio-vascular
- (anaphylaxis)
• Nonimmediate DHR > 6hrs
- AGEP: 24-72
- MPE: 7-11 days
- SJS/TEN (blistering): 10-25 days
- DRESS: 10-50 days
AGEP: acute generalized exanthematous pustulosis
SJS: Steven Johnson syndrome
TEN: toxic epidermal necrolysis
DRESS: drug reaction with eosinophilia and systemic symptoms
DELAYED SKIN REACTION
3
, DIFFERENT CLINICS & DIAGNOSTICS
• Type I:
- Mast cells / basophils
- might be IgE mediated*
- IgE tests (if available)
- Immediate readings skin tests (SPT and IDT, no patch)
*many alternative mechanisms (that are generally difficult, if at all, demonstrable !!!
• Type IV:
- T cells and others
- IgE- test: useless
- Delayed readings skin test (patch & IDT) (prick test is useless)
! red man syndrome -> type II reaction, not IgE reaction (kan vermeden worden door vancomycine traag toe te
dienen!
4
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller mh14. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.25. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
56326 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now