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Summary Cytologie en histologie - Cytologie en histologie
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samenvatting van het boek, de dia's en de hoorcolleges van prof Calders
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Hoofdstuk 8: embryologie Verloop in fasen1. Bevruchting
1. Bevruchting 2. Embryonale ontwikkeling
= Grote instroom van Calcium Eerste klievingen
- Vrouw: 1 eicel door eisprong naar buiten Latere embryonale stadia
( door eitrechter en eileider naar baarmoeder) 3. Post embryonale
- Man: zaadcellen door zaadlozing 1 vrouw ontwikkeling
Groei
- Acrosoomreactie Veroudering
= mantel spermatozoön verwijdert in buurt van oöcyt Dood
- Fase 1:
= penetratie corona radiata
Enzym hyaluronidase + activiteit spermatozoön
- Fase 2:
= penetratie zona pellucida
Enzym zona-lysine + trypsine -> lost pellucide op = zonareactie
- Fase 3:
= fusie spermatozoön en oöcyt
2 celmembranen versmelten, celmembraan spermatozoön blijft achter
In 3 reacties
1. Corticale en zonale reacties
Door corticale oöcytgranula
>membraan oöcyt = ondoordringbaar
>structuur zona pellucida verandert
2. Hervatten 2de meiotische deling
=>2de poollichaampje
>chromosomen rangschikken in vesiculaire nucleus = pronucleus
3. Activeren metabolisme
Mannelijk pronucleus -> vrouwelijke pronucleus
Proucleus DNA verdubbelen -> mitose
Splitsen van beide cellen
2. Embryonale ontwikkeling
- Eerste klievingen
A. Morula fase
snel opeenvolgende mitoses
geen groei
vormen morula
B. blastula fase
blastomeren vormen
scheiden vloeistof af => bol rond holte
holte = blastocoel
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