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Exam (effects) Cell Biology and Immunology (AB_1132)
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Oefenvragen immuniteit1. What is NOT a characteristic of the innate immune system?
A. fast
B. present in the tissues
C. a specific
D. memory
2. The secondary lymphoid organs are important for:
A. initiation of innate immunity
B. development of adaptive immunity
C. activation of adaptive immunity
D. activation of both innate and adaptive immunity
3. Which innate immune cells work together for bacterial clearance upon
infection?
A. Macrophages and neutrophils
B. Macrophages and NK cells
C. Neutrophils and NK cells
D. NK cells and CTL
4. Which of the following characteristics belong to dendritic cells?
A. Immature dendritic cells excel in antigen presentation to T cells
B. Mature dendritic cells excel in antigen presentation to T cells
C. Mature dendritic cells excel in phagocytosis of pathogens
D. Immature dendritic cells excel in migration of lymph nodes to skin
5. The complement factor C3 is cleaved into C3a and C3b for activation.
What is the function of C3a?
A. It is an anaphylatoxin which induces cytotoxicity for pathogen killing
B. It recruits phagocytes to the site of infection
C. It induces complement fixation for enhanced phagocytosis
D. It recruits bacteria towards macrophages for phagocytosis
6. T cell receptors (TCR) recognize:
A. intact antigens.
B. intact antigens in the context of MHC.
C. peptide fragments.
D. peptide fragments in the context of MHC.
7. Why is an effector CD8+ T cell (CTL) able to kill every cell that harbors a
replicating virus?
A. The pathogen is present in the extracellular space
B. CTL enable macrophages to kill intracellular pathogens
C. The peptides of the pathogen are loaded in MHC class I molecules in the ER
D. The infected cells express increased levels of MHC class II molecules
, 8. Which statement(s) is/are correct? I: extracellular antigens are loaded on
MHC II in vesicles following processing II: intracellular antigens are
degraded by proteases upon acidification III: MHC I loading can only occur
when peptides are transported to the ER via TAP
A. I is correct
B. I and III are correct
C. II and III are correct
D. All statements are correct
9. A vaccine for SARS-CoV-2 in clinical trials generated neutralizing IgG
antibodies, antigen-specific CD8+ cytotoxic T effector cells, and memory B
cells. Which statement is correct?
A. CD4+ T cells were unlikely to have been activated by the vaccine.
B. Peptides generated from the SARS-CoV-2 vaccine were presented in MHC class
II molecules.
C. Neutralizing antibodies provide protection by activating complement.
D. Dendritic cells did not need to be activated by the vaccine to produce
neutralizing antibodies or CD8+ effector T cells.
10.Positive selection in the thymus is important to:
A. eliminate autoreactive T cells
B. activate autoreactive T cells prior to apoptosis induction
C. ensure recognition of self-MHC molecules by T cells
D. remove T cells which react to self-MHC molecules
11.Effector T cells recognize antigen in peripheral tissues. For this they
require:
A. Recognition of the antigen in MHC by the TCR.
B. recognition of MHC and co-stimulation.
C. only co-stimulation.
D. Recognition of the antigen in MHC by the TCR plus co-stimulation
12.T helper 2 cells …
A. activate macrophages.
B. activate neutrophils.
C. activate B cells.
D. stimulate cytotoxicity.
13.Somatic recombination is important for:
A. generation of high variety in the TCR repertoire
B. generation of high variety in the HLA repertoire
C. activation of only pathogen specific T cells
D. development of T cells which express a combination of many TCR
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