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NR 565 - ADVANCED PHARMACOLOGY MIDTERM - CHAMBERLAIN
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NR 565 - ADVANCED PHARMACOLOGY MIDTERM - CHAMBERLAIN
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NR 565 - ADVANCED PHARMACOLOGYMIDTERM - CHAMBERLAIN
Duringpowhatpotrimesterpoispoapopregnantpowomanpomostpoatporiskpoforpoadversepodrugpor
eactionspowithpopotentialpolongpotermpoconsequences?po-poans--
1stpotrimesterpo(fetuspomostpoatporiskpod/tporapidpogrowth)
WhatpoispoBEERSpocriteria?po-poans--
Recommendationspoofpomedicationspoinappropriatepoforpoelderlypo(65poandpoolder),popre
scriberpoultimatelypodecides
WhatpoispothepoCYP450po(cytochromepoP450)po-poans--
liverpoenzymeposystempowherepomedicationspoarepometabolized,pocanpoeitherpobepoinduc
erspoorpoinhibitorspoandpocreatepodrug-drugpointeractions
CYP450poinducerspo-poans--
Speedpouppometabolismpoofpodrugspo(drugpoispoclearedpofaster),podrugpohaspolesserpoeffe
ctpo(decreasepobloodpolevelspoofpodrug),poelevatepoCYP450poenzymes
CYP450poinducerspopneumonicpo-poans--"BullshitpoCrappoGPSpoINDUCESporage"
CYP450poinducerpodrugponamespo-poans--
Barbituates,poStpoJohnpowort,poCarbamazepine,porifampin,poalcohol,pophenytoin,pogriseof
ulvin,pophenobarbital,posulfonylureas
CYP450poinhibitorspo-poans--
inhibitpometabolism,poincreasepobloodpolevelspoofpomedications
CYP450popneumonicpo-
poans--"VISApocreditpocardpodebtpoINHIBITSpospendingpoonpodesignerspolikepoCKpotopoloo
kpoGQ"
CYP450poinhibitorspodrugponamespo-poans--
Valproate,poisoniazid,posulfonamides,poamiodarone,pochloramphenicol,poketoconazole,po
grapefruitpojuice,poquinidine
,Physiologicalpochangespoduringpopregnancypothatpoimpactpopharmacodynamicspoandpop
harmacokineticpopropertiespoofpodrugs?po-poans--
increasepoglomerularpofiltrationporatepoleadspotopoincreasepodurgpoexcretionpo
increasepohepaticpometabolism
decreasepotonepoandpomotilitypoofpobowel
increasepodrugpoabsorption
Examplespoofpomedicationspothatpocanpobepoteratogenicpo-poans--
Antiepilepticpodrugs,poantimicrobialsposuchpoaspotetracyclinespoandpofluoroquinolones,povi
taminpoApoinpolargepodoses,posomepoanticoagulants,poandpohormonalpomedicationsposuch
poaspodiethylstilbestrolpo(DES).
Howpoispoabsorptionpoofpointramuscularpomedicationspodifferentpoinponeonates?po-poans--
slowpoandpoerraticpoduepotopolowpobloodpoflowpoinpomusclespofirstpofewpodayspoofpolife
Whypoispoabsorptionpoofpomedicationpoinpothepostomachpoincreasedpoinpoinfancy?po-
poans--delayedpogastricpoemptying
Somepomedicationspothatposhouldpobepoavoidedpoinpothepopediatricpopatient?po-poans--
glucocorticoids,podiscolorationpoofpodevelopingpoteethpowithpotetracyclines,poandpokernict
eruspowithposulfonamides,polevofloxacinpo(antibiotics)po
aspirinpo(Severepointoxicationpofrompoacutepooverdose)
whatposhouldpobepoincludedpoinpomedicationpoadministrationpopatientpoeducation?po-
poans--dosageposizepoandpotiming
routepoandpotechniquepoofpoadministration
durationpoofpotreatment
drugpostorage
naturepoandpotimepocoursepoofpodesiredporesponses
naturepoandpotimepocoursepoofpoadverseporesponses
finishpotakingpoantibiotic
Whatpoareposomepothingspothatpoputpothepoelderlypopatientpoatpohigherporiskpoforpoadverse
podrugporeactions?po-poans--reducedporenalpofunctionpo
polypharmacypo(thepousepoofpofivepoorpomorepomedicationspodaily)
greaterposeveritypoofpoillness
presencepoofpocomorbidities
usepoofpodrugspothatpohavepoapolowpotherapeuticpoindexpo(e.g.,podigoxin)
increasedpoindividualpovariationposecondarypotopoalteredpopharmacokinetics
inadequateposupervisionpoofpolong-termpotherapy
poorpopatientpoadherence
Howpocanpohealthcarepoproviderspodecreasepolikelihoodpoofpoanpoelderlypopatientpoexperi
encingpoanpoadversepodrugporeaction?po-poans--
obtainingpoapothoroughpodrugpohistorypothatpoincludespoover-the-counterpomedications
consideringpopharmacokineticpoandpopharmacodynamicspochangespoduepotopoage
, monitoringpothepopatient'spoclinicalporesponsepoandpoplasmapodrugpolevels
usingpotheposimplestporegimenpopossible
monitoringpoforpodrug-drugpointeractionspoandpoiatrogenicpoillness
periodicallyporeviewingpotheponeedpoforpocontinuedpodrugpotherapy
encouragingpothepopatientpotopodisposepoofpooldpomedications
takingpostepspotopopromotepoadherencepoandpotopoavoidpodrugspoonpothepoBeerspolist
Howpocanpowepopromotepomedicationpoadherencepowithpoelderlypopatients?po-poans--
simplifyingpodrugporegimens
providingpoclearpoandpoconcisepoverbalpoandpowrittenpoinstructions
usingpoanpoappropriatepodosagepoform
clearlypolabelingpoandpodispensingpoeasy-to-openpocontainers
developingpodailyporeminders
monitoringpofrequently
affordabilitypoofpodrugs
supportposystems
Whypodoponitratesponeedpotopobepotakenponopolaterpothanpo4poPM?po-poans--
Needponitratepofreepointervalposopotolerancepodoesn'tpodevelop
Ninepofactorspothatpoimpactpooutcomepoofpomedication?po-poans--Genderpoandporace
Geneticspoandpopharmacogenomics
Variabilitypoinpoabsorption
placebopoeffect
Tolerance
patho
age
bodyweight
Dopoyouponeedpoinformedpoconsentpoforpogeneticpotesting?po-poans--yes
WhatpoispothepopurposepoofpothepoGeneticpoInformationpoNon-DiscriminatorypoAct?po-
poans--
Protectspopatientspofrompodiscriminationpobypoemployerspoandpoinsurancepoproviderspoba
sedpoonpogeneticpoinformation
Differencepobetweenpopracticepoauthoritypoandpoprescriptivepoauthority?po-poans--
Practicepoauthorityporeferspotopotheponursepopractitioner'spoabilitypotopopracticepowithoutpo
physicianpooversight,powhereaspoprescriptivepoauthorityporeferspotopotheponursepopractitio
ner'spoauthoritypotopoprescribepomedicationspoindependentlypoandpowithoutpolimitations.
Whoporegulatespoprescriptivepoauthority?po-poans--
thepojurisdictionpoofpoapohealthpoprofessionalpoboard.poThispomaypobepothepoStatepoBoard
poofpoNursing,pothepoStatepoBoardpoofpoMedicine,poorpothepoStatepoBoardpoofpoPharmacy,p
oaspodeterminedpobypoeachpostate.
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