Samenvatting van oncologie. tweedejaars vak op de master farmacie in Leiden. Het is een beknopte samenvatting. Aan bod komt de agho lijst, melanoom, longcarcinoom, prostaatcarcinoom, borstcarcinoom, (orale) oncolytica, klassieke oncolytica (chemo), immuuntherapie en meer
HDAC :
de-acetyleat historen - >
onder drukt transcriptie
celcyclus :
G1 fase :
replicatie organelle
S Fase : DNA replicate
G Fase :
productie benodigde enzymen
M Fase : Mitose + Cytokinese : delen in 2 cellen
Checkpoint inhibitors :
Cycline + CDK binding , dan pas door na volgend
Fase
cycline D + CD 4/6 -
> door de G1
E + CDr 2 G1 -S
Cycline -
-1
door des
CyclireA + CDk 2
Cyclise A/B + CDk1 - G2 - m
61 checkpoint :
RB is
Zondergroeisignaal :
gehypofosforgleed
-
>
binding Elf en HDAC
↳ anderdrukt transcriptie
P53 Is Pri = (DK RB-onderdrukking transcriptie
met groeisignaal : Cycline DIE + CDK4/6 en 2
fosforgleren RB vrijkomen E2F en HDAL
,
WEE1 "activeert (DK1-1 apoptose
WEE1 remmers ic carbopl -> drukt de cel mitose in met mutaties v.
Carboplat ->
apoptose
schade : Cycline B + CDK 1 complex - door naar m Fase
geen
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