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"Sickle Cell Anemia: Pathophysiology, Management, and Nursing Interventions"

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This document provides a detailed overview of sickle cell anemia, focusing on its pathophysiology, clinical manifestations, diagnostic methods, and management strategies. It explains the genetic basis of sickle cell disease, the sickling of red blood cells, and the resulting complications such as v...

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  • December 22, 2024
  • 5
  • 2024/2025
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SICKLE CELL ANEMIA
Sickle cell anemia is a severe hemolytic anemia that results from inheritance,
autosomal recessive, of the sickle hemoglobin gene, hemoglobin (HbS).
Characteristics:
• Sickle shaped; sticky



• sensitive to low O2




• lifespan: 20days

, ETIOLOGY:
• Presence of HbSS indicates active disease while HbAS indicates sickle cell tra
• Black population.
• lesser extent in people from the Middle East, the Mediterranean area, and ab
tribes in India.

PATHOPHYSIOLOGY: NORMAL hemoglobin
HbA
ABNORMAL hemoglob
HbS


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