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samenvatting revaki reuma, deel OA, 3de bach REVAKI $7.69
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samenvatting revaki reuma, deel OA, 3de bach REVAKI

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samenvatting revalidatie en kinesitherapie van het reumatologisch stelsel, deel osteo-artritis (OA) (pathogenese, kliniek, epidemiologie, behandeling + revalidatie), eigen notities+ ppt, samenvatting is aangepast na het studeren!!

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  • December 26, 2024
  • 13
  • 2024/2025
  • Summary
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REVAKI-REUMA
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Osteo-arthritis (OA)




1

, Pathogenese, kliniek,
epidemiologie, behandeling OA
1. Situering
 Meest frequente chronische gewrichtsaandoening
 Prevalentie neemt toe met leeftijd
 Socio-economische impact

2. Etiologie
OA= actieve, degradatieve & reparatieve processen vh kraakbeen & subchondraal bot met
synoviale inflammatie (ontsteking vh gewricht)
 Goede balans tssn afbraak & reparatie processen
 Balans uit evenwicht? Normaal gewricht wordt osteo-artritis gewricht
 Grootste risico’s:
- Mechanische stress: slijtage door bewegen
- Biomechanisch: andere stand v gewricht (X-benen)
- Genetisch: bepaalde families meer voorbeschiktheid
 Na verloop te veel afbraak v kraakbeen
 Chrondrocyt geactiveerd
 Nog meer afbrekende stoffen komen vrij: degradatie-enzymen
 Pro-inflammatoire cytokines, proteïnase
 Macroscopische symptomen:
- afbraak vh kraakbeen
- hypertrofische reactie (sclerose) v subchondraal bot
- nieuwe botvorming (osteofyten)
 whole organ disease: gewricht beschouwd als orgaan
- spierzwakte
- laxe ligamenten
- laaggradige synovitis
- meniscus degeneratie
- neurosensoriële veranderingen
2.1. Pathologie OA
 Normaal kraakbeen: helder doorzichtig, glanzend & goed bevochtigd
 Extra-cellulaire matrix= steunweefsel:
- Collageen
- Proteoglycanen


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