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Selfstudy assignment answers lecture 16-17
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Check ppt for the right answers2. with the adoptive T-cell therapy you need the tumor cells present
because you inject with CAR T-cells and there is no tumor then the it
doesn’t do anything. DC-based therapy can also be used to prevent cancer
and antibody mediated therapy is targeted against the immune therapy to
make it better
9. in B you inject altered T-cells and it is possible that your immune system
will recognize that.
10. If you put a lot of pressure on something it will lead to reduced
expression after a while. A and B so as soon as your targeteing one
specific thing, for example pdl1 a receptor on a tumor. If you use a lot of
antibodies on this receptor then it is beneficial for the tumor to reduce the
expression of pdl1. With DC you’re not activating a specific think but you
activate a whole immuneresponse and this will target tumors and these
have multiple receptors so not that specific and then it is hard for the
tumor to do something about this.
14. in A and B youre targeting one specific thing and with C you can attack
and eradicate the tumor in many different wanys. With DC youre activating
the whole immune system.
Con 8. With B you’re injecting the killers and these can also kill healthy
cells. The target of the CAR T-cell can also be the target expressed on B
cells in the case of blood cancers. That’s why it might attact healthy cells
aswell.
Antibody mediated therapy
Pros
1. This form of treatment specifically targets a particular part of the
immune system.
2. Is already approved for the treatment of multiple forms of cancers.
3. Is well suited to be used in combination with chemotherapy and/or
radiotherapy.
8. This immunotherapeutic agent directly targets and attacks the tumor.
11. This therapeutic agent can be exploited as a carrier to facilitate the
delivery of other anti-tumor compounds to the tumor.
13. Can be directed to multiple tumor antigens at the same time.
Cons
3. Compared to other immunotherapeutic treatment modalities, this
treatment has relatively more severe adverse side effects.
8. Also, healthy cells can be destroyed (due to off-target effects).
9. There is the possibility that the immune system will mount a response
against the therapeutic agent, impairing its efficacy.
10. The therapy can lead, as an unwanted side effect, to a reduction of the
expression of the therapeutic target.
Adoptive T cell Therapy
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