A child with dysmorphic thumbs is newly dx with myelodyplastic syndrome. What does
the RN anticipate an additional evaluation for? - answer Fanconi Anemia
Von Willebrand is missing... - answer V, W factor
Iron def & Thalassemia: What are the lab differences between them - answer Iron
def- Fe & ferritin levels are low
Thalassemia- Fe & ferritin levels are both normal to high
3 Factors that increase risk of thromboembolism - answer Factor V Leiden
Protein C & S deficiency
Protein C & S act as Vitamin K dependent proteins which are anticoagulants
Thalassemia : How does it gets transmitted genetically? - answer B-Thal =
autosomal recessive
SCD: What is the main symptom of spleenic infarction with SCD disease? - answer
ULQ pain, severe
Pneumocystis Pneumonia: The causative organism of - answer A Fungus
Amylase & lipase : what are they - answer Amylase- breakdown starches
Lipase- digest fats
What electrolytes have an inverse relationship with each other? - answer potassium -
magnesium
Phosphate-calcium
Sodium-water
PTT-fibrinogen
Eosinophils: purpose - answer Prominent in allergic rxs
Can selectively destroy parasites/ have function in immediate allergic/hypersensitivity
reactions/ produced prifivrinolysin - form fubrinolysin - digests fibrin- dissolves clots
a lymphocyte
They are circulated through the thymus gland- ralidly- divide & produce T-cells that are
sensituzed to antigen-killer cells- play a role in body's resistance to proliferation of
cancer cells
Malignant stem cells are - answer Cells that lose the ability to regulate cell division
and differentiate to mature functioning cells
Blasts accumulate where and what does this cause - answer Marrow spaces,
peripheral vasculature, and organs
Normal cell proliferation is blocked d/t lack of space/nutrients
Diploid - answer 46 chromosomes
G6PD: A ______ retic count and _____Coombs test are found in glucose 6 phosphate
deficiency - answer High; negative
Pseudodiploid - answer 46 chromosomes with structural changes
Hyperdiploidy and prognosis - answer Fewer than 50 chromosomes and good
prognosis
, Platelet life span - answer 7-10 days
Lymphocytes - answer Involved in development of antibodies and delayed
hypersensitivity
RBC lifespan - answer 120 days (4 months)
Hemoglobin is broken down into - answer Iron- iron is used by bone marrow to make
more RBC and bilirubin which is excreted by liver as bile
Erythopoietin: What happens when it is released into the bloodstream - answer It
stimulates the bone marrow to make new RBCs
Basophils - answer Healing phase of inflammation- become mast cells on tissue-
responsible for histamine release- allows WBCs to exit vessels at site of injury
Erythropoietin is produced by _____in response to_____ - answer Kidneys
Tissue Hypoxia
Platelets decrease after chemo - answer 7-21 days
Cancer cell deviations - answer No present number of divisions before death
Not inhibited by contact
Don't require usual amount of growth factors- some produce their own
Elevated retic count without tissue hypoxia/increased destruction of RBC - answer
Could indicate BM failure
Retic Count - answer Production if RBC by bone marrow
Platelets release - answer Serotonin- which causes vasoconstriction
Epoiten alfa - answer Boots Hgb levels in place of transfusion
Fanconi's anemia may not be diagnosed until they present with these diseases - answer
Myelodysplastic syndrome
Acute Myelogenous leukemia
Which of the following findings is consistent with a dx of autoimmune hemolytic anemia?
-Negative coombs test
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