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CPHON-Hematology Questions and Answers
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CPHON-Hematology Questions and Answers Bone Marrow Failure: examples of Autoimmune hemolytic anemia, fanconi's anemia, dyskeratosis congentia, shwachman-diamond syndrome Platelet/ coagulation diseases ITP, Thrombosis, thrombophilia, hemophilia, VWD RBC disease: examples SCD, thala...

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  • December 31, 2024
  • 22
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • cphon hematology questions and answers
  • bone marrow failure examples of autoimmune hemoly
  • platelet coagulation diseases itp thrombosis th

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CPHON-Hematology Questions and
Answers
Bone Marrow Failure: examples of - answer Autoimmune hemolytic anemia,
fanconi's anemia, dyskeratosis congentia, shwachman-diamond syndrome

Platelet/ coagulation diseases - answer ITP, Thrombosis, thrombophilia, hemophilia,
VWD

RBC disease: examples - answer SCD, thalassemia, Glucose 6-phosphate
dehydrogenase deficiency, heredity spherocytosis

A child with dysmorphic thumbs is newly dx with myelodyplastic syndrome. What does
the RN anticipate an additional evaluation for? - answer Fanconi Anemia

Von Willebrand is missing... - answer V, W factor

Iron def & Thalassemia: What are the lab differences between them - answer Iron
def- Fe & ferritin levels are low

Thalassemia- Fe & ferritin levels are both normal to high

3 Factors that increase risk of thromboembolism - answer Factor V Leiden
Protein C & S deficiency

Protein C & S act as Vitamin K dependent proteins which are anticoagulants

Thalassemia : How does it gets transmitted genetically? - answer B-Thal =
autosomal recessive

SCD: What is the main symptom of spleenic infarction with SCD disease? - answer
ULQ pain, severe

Pneumocystis Pneumonia: The causative organism of - answer A Fungus

Amylase & lipase : what are they - answer Amylase- breakdown starches

Lipase- digest fats

What electrolytes have an inverse relationship with each other? - answer potassium -
magnesium
Phosphate-calcium
Sodium-water
PTT-fibrinogen

,B cells purpose - answer Humoral immunity- makes antibodies, memory cells

Eosinophils: purpose - answer Prominent in allergic rxs

Can selectively destroy parasites/ have function in immediate allergic/hypersensitivity
reactions/ produced prifivrinolysin - form fubrinolysin - digests fibrin- dissolves clots

Stem cells mature into - answer RBC, granulocytes, monocytes, lymphocytes, plts

Monocytes purpose - answer Phagocytosis
Large phagocytic cells involved in early stage of inflammatory reaction

natural killer cells (NK cells) purpose - answer Destroy viruses & malignant cells non
specifically

Neutrophils purpose - answer Ingest & destroy microorganisms, primary defense
against bacterial infections

Primary defense in infection/phagocytize and kill bacteria

T lymphocytes (T cells) purpose - answer Cell mediated immunity- attacks invaders

a lymphocyte
They are circulated through the thymus gland- ralidly- divide & produce T-cells that are
sensituzed to antigen-killer cells- play a role in body's resistance to proliferation of
cancer cells

Malignant stem cells are - answer Cells that lose the ability to regulate cell division
and differentiate to mature functioning cells

Blasts accumulate where and what does this cause - answer Marrow spaces,
peripheral vasculature, and organs

Normal cell proliferation is blocked d/t lack of space/nutrients

Diploid - answer 46 chromosomes

G6PD: A ______ retic count and _____Coombs test are found in glucose 6 phosphate
deficiency - answer High; negative

Pseudodiploid - answer 46 chromosomes with structural changes

Hyperdiploidy and prognosis - answer Fewer than 50 chromosomes and good
prognosis

, Platelet life span - answer 7-10 days

Lymphocytes - answer Involved in development of antibodies and delayed
hypersensitivity

RBC lifespan - answer 120 days (4 months)

Hemoglobin is broken down into - answer Iron- iron is used by bone marrow to make
more RBC and bilirubin which is excreted by liver as bile

Erythopoietin: What happens when it is released into the bloodstream - answer It
stimulates the bone marrow to make new RBCs

Basophils - answer Healing phase of inflammation- become mast cells on tissue-
responsible for histamine release- allows WBCs to exit vessels at site of injury

Erythropoietin is produced by _____in response to_____ - answer Kidneys
Tissue Hypoxia

Platelets decrease after chemo - answer 7-21 days

Cancer cell deviations - answer No present number of divisions before death
Not inhibited by contact
Don't require usual amount of growth factors- some produce their own

Elevated retic count without tissue hypoxia/increased destruction of RBC - answer
Could indicate BM failure

Retic Count - answer Production if RBC by bone marrow

Platelets release - answer Serotonin- which causes vasoconstriction

Granulocytes - answer Neutrophils, basophils, esoninophils

survive in bld 1214 hrs
in tissues 5 days

Epoiten alfa - answer Boots Hgb levels in place of transfusion

Fanconi's anemia may not be diagnosed until they present with these diseases - answer
Myelodysplastic syndrome
Acute Myelogenous leukemia

Which of the following findings is consistent with a dx of autoimmune hemolytic anemia?

-Negative coombs test

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