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CPHON Study Guide Questions and Answers
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CPHON Study Guide Questions and Answers What does Hydroxyurea stimulate? fetal hgb What is Rituximab? Monoclonal antibody acts against CD20 used for Burkitts Lymphoma Where is erythropoietin produced? kidneys epryhropoietin: regulates and controls the production of maturation...

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  • January 1, 2025
  • 19
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • cphon study guide questions and answers
  • what is rituximab monoclonal antibody acts agains
  • where is erythropoietin produced kidneys epryhro

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  • CPHON

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CPHON Study Guide Questions and
Answers
What does Hydroxyurea stimulate? - answer fetal hgb

What is Rituximab? - answer Monoclonal antibody
acts against CD20
used for Burkitts Lymphoma

Where is erythropoietin produced? - answer kidneys

epryhropoietin: regulates and controls the production of maturation of RBCs

What is Septra and Dapsone for? - answer to prevent pneumocystis jiroveci.

What can Septra (Bactrim) cause? - answer bone marrow suppression

Imatinib is best treatment for.... - answer CML

What can Tacrolimus cause? - answer reversible posterior encephalopathy

Dactinomycin can cause? - answer radiation recall

Bleomycin can cause? - answer pulmonary fibrosis. Make sure to tell anesthesia
before being put to sleep. You cannot hyper oxygenate bc it will make it worse.

What chemos have a max dose? - answer Bleomycin
Doxorubicin 550mg/m2

What can Asparaginase cause? - answer Pancreatitis and High blood sugar

What can VP16 cause? - answer secondary AML

Alkylating agents are responsible for... - answer fertility issues. Think of transplant
chemos and high dose chemos like cisplatin, ifosphamide

What is the first line of treatment for hemolytic anemia? - answer Steroids

What drug is given for iron overload? - answer Deferoxamine it is a chelating agent

Most common childhood cancer? - answer ALL

Most common solid tumor cancer? - answer Brain tumors

,Astrocytoma: most common brain tumor
Medulloblastoma: most common malignant brain tumor

Most common extracranial solid tumor? - answer NB

Alkylating Agents.... - answer interrupts the cell cycle
cytoxan (cycle)
Ifosfamide
Lomustine
Carmustine
Buslfan
Procarbazine
Temozolimide
Decarbazine
Cisplatin
Carboplatin

Antitumor Antiboitics.... - answer interfere with cell metabolism
Dactinomycin
Bleomycin
Daunorubicin
Doxorubicin
Idarubicin

Antimetabolites.... - answer Stops the ability at the nucleus
5FU
6MP
Gemcitabine
Fludarabine
Cytrarbine
Hydroxyurea
Methotrexate

Plant Alkaloids.... - answer cause DNA breakdown
VP16
Paclitaxel
Docetaxel
Topotecan
Irinotecan
Vincristine:max single dose 2mg
Vinblastine
Vinorelbine

Miscellaneous... - answer mechanisms not understood
Asparaginase
Retinoids

, Imatinib (Gleevac)

Ambisome - answer antifungal
check K

think about pt on antibiotics for 1 week and still having F/N think fungal

What are Biologic Response Modifiers (BRM)? - answer attack targeted pathways
and tumor receptor sites

What scan is gold standard with NB? - answer MIBG

What is Flagyl used for? - answer Cdiff

Tacrolimus side effects? - answer Hypomagnesium
Hearling loss
Dizzy

What does Mag sulfate prevent with Cisplatin? - answer leg cramps

Labs associated with DIC - answer Increased: PT, PTT, D-Dimer
Decreased: Platlets, Fibrinogen

What antibiotic do you use for a line infection? - answer PCN

Pt is 10 days post transplant with pulmonary edema...what was the cause? - answer
Capillary leak syndrome from chemo

What is myeloablation therapy? - answer completely wiping out the system
preps against GVHD
ATG

prepares the bone marrow for transplant by destroying the patients circulating T
lymphocytes

What are B and T lymphocytes deficit in? - answer antibodies

Best treatment if necrotic tissue around a tumor? - answer surgery

Clinical Trials - answer 1. Max tolerated dose
2. tx on specific disease. Must have measurable diagnosis
3. new tx vs standard tx

Why limit platelet transfusions? - answer to prevent alloimmunization

also think single platelet donor

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