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Samenvatting geneesmiddelen tabel - cholesterol
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Samenvatting van 2 pagina's voor het vak Verpleegkundige zorg en Communicatie 2 aan de HoGent (cholesterol)
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IP Werking FarmacaStatines
Fibraten - Agonisten van nucleaire PPAR - Hyperlipen
– alfa - Lipanthyl
- PPAR- alfa: verantwoordelijk
voor de genexpressie van
verschillende enzymen
betrokken bij het
lipidenmetabolisme, maar
exact mechanisme is niet
gekend.
- Minder cholesterolverlagend,
wel triglyceridenverlagend
Anionuitwisselaars = - Binden galzouten in de darm Questran
glazuurbindende harsen en onderbreken zo hun
entero-hepatische cyclus
zonder zelf opgenomen te
worden (en zullen via faeces
darm verlaten)
lever maakt meer
galzuren aan uit
cholesterol dus moet LDL
uit bloed halen om zelf
voldoende cholesterol te
hebben
Ezetimibe = - inhibeert selectief de Ezetrol
cholesterolabosrptieremmer intesinale resorptie van
cholesterol en zal wel door
lever gemetaboliseerd
worden via gal uitgescheden
- daling van cholesterol en LDL
cholesterol
- weinig effect op triglyceriden
en HDL cholesterol
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