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Summary Drug Profile Summaries with Mechanism of Action, Pharmacokinetics, Monitoring, Counselling and Interactions $8.79
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Summary Drug Profile Summaries with Mechanism of Action, Pharmacokinetics, Monitoring, Counselling and Interactions

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Comprehensive Drug Profile Summaries – Key Insights in One Page (Information from this information may have changed since) These one-page drug profile summaries are perfect for students, healthcare professionals, and anyone looking for a quick reference to understand essential drug informat...

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  • January 3, 2025
  • 12
  • 2023/2024
  • Summary
  • Unknown

1  review

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By: loisvobe • 10 hours ago

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DRUG : Lisinopril ClASS : ACEi




MECHANISM OF ACTION INDICATION FOR USE :

* Inhibts
Antiogensen Conversion >
-
Inhibte
Antigensen 11
Hypertension- 55
- Prevention
>
- Secondary
Decrease Infarction
ADH Decrease vasoconstriction
Myocardial S h o r t-te r m must be
heamodynamically
-



Stable
↓ Decrease aldosterone


Decree
20 ↳ ↓ Total peripheral
Nattzoreabsorption resistana re Renal Complication of Diabetes Mellitus

↓ # ↓
Volume ↓
↓ Blood volume Blood Preload

- Higlod pressure

Heart Failure -
> With Beta Blockers




DOSAGES :


* Low and Slow >
-
Avoid
hypotensionSysidroa b
HTN-lOmg
3 80mg may
* OD inital - At bedtime



1Omg
OD Mainee


diuretic-2 55 mgoDivitazong ,
a
.




Another Safter first
* MI
Systolic BP > 120 - Smg within 24 hours - done

>
-


long after second dose - Maintained for 6 We e ks



CONTRAINDICATIONS : > Reduce to 5 or 2 5 it BP <100
-
.




* Renal Complications in DM 2 Op-oInital
5-5mg
- .




Black African
Hereditary /idiopathic angioedema African-Caribbean Usual
10-20mg OD Based
*
> dose
or response
-


-> - on


-
* eGFR < 60mL/min Elderly
* Hear t Failure/adjunct 2 OD Stepped
33Smaa
Inital
Smg
>
-

-
. - up
Combination weems
e
* With aliskiren i n DM
long at 2
>
least
-




every
Prosistent
typotention
a
*
Elderly with

-Hyperkalaemia
a
* ConditionArticsens hypertension

↳Pregnaa , ma




INTERACTIONS ROUTE OF ADMIN T PHARMACOKINETICS
ALISKERIN Risk of impairment
hypokalemia hypotension + renal
-
,




DIURETICS -
Rapid fall in BP in volume-depleted patient * Oral -- 25 %
Bioavailability
-
> Initiate at low close

=PeakPlasma
o a


ALLOPURINRiskLeucopeiathypersensitive it
* Water soluble metabolized
Not
by Liver
->




NSAIDS - Risk
of renal impairment + c a n cancel out
antihypertensive effectn
>
-

Renal excretion
unchanged
MTORINHIBTORS ↑Risk
of angio-oedema
-




SUNORA Hypoglycaemic
eft



HEPARIN -
Hyperkalemia
be uned after 36 hours
SACBUTRIL - Can
only of dose


SPIRONOLACTONE - Risk of
hyperkaldenia




COUNSELING POINTS+ MONITORING ADVERSEEFICTS :
* With or without food
COMMON
Common AgranRetosis
-




* First dose before bed >
Hypotension
*
Angio-odema * Namea




injit
-




*
Alopecia * Palpitation
* Whole drink
of water * Hepatitis


AngieaRenalimpair
a

Misseddo As sonanYourember a
double do ,

* Fever
unction
eucope
a



zay
↳ n a
Dysphagia
*
Pancytopenia
Heamolytic andemia
.

* Stand up Slowly *

*
Photosensitivity *
Hyperhidrosis Thrombocytopeninaen syndrome
Phil
* Contact doctor
Dry Cough ->


ora
* Check BP often
* MI
MONITORING * Stroke



Realfunction3 Before and
during treate a
* Gl discomfort

, DRUG : Losartan CIASS : ARB




MECHANISM OF ACTION INDICATION FOR USE :

Reversible competitive binds to AT1 to b l o c k
antigens i n I ① Diabetic
neuropatry in
Type
2





cares vascular smooth muscle ② Chronic HF when Acti are unsuitable

relaxation =
NBP



③ HTN ->
including strove risk reduc tion




④ HIN with intravascular volume depletion




CONTRAINDICATIONS : DOSAGES :

eGFR

Patents
less than

on
60mL/min/1 73 m2

aliskiren >
-
DM .
.




①autnitogndetogoD
Pregnancy - ② Initial 12 .




5mg OD - & to up to
150mg at
weekly
intervals .



CAUTIONS ③tautitaSongtimea
Masterial ④ Initial
25mg
OD > to
100mg
if needed.
-



hypona




Bach Africaria
a




INTERACTIONS ROUTE OF ADMIN T PHARMACOKINETICS



AliskerRiskfyanSe
Acti 33 % Oral
+
bioavalability


Tmax
of
3-4 hous (AP)




>M Risk (YP450s
Diuretics
of
volume depletion
+they potension Metabolised
by
-




6-9
Lithium >
-

↑ Serum lithium concentration Half life hours




NSAIDS/COX2 inhibitors + ↑
Worsening of renal function -
Hyperkalemia




COUNSELING POINTS :

COMMON AE MONITORING COUNSELLING



rain
is Pottasium levels Before Bedtime first dom


↳Dizzinesa

Espically i n elderly +
re n a l impairment
sometime




Ma
Missed

a
a
doseTake S bu dose

Don't step abruptly.
Namea +
Vomiting



paina

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