,Table of Contents
1 Diabetes: definitie, classificatie en diagnose................................................................................................ 6
Definitie.................................................................................................................................................................6
Epidemiologie.......................................................................................................................................................6
Risicoinschatting...................................................................................................................................................6
Diagnose...............................................................................................................................................................6
Types.....................................................................................................................................................................7
Zwangerschapsdiabetes.......................................................................................................................................7
Monogenetische vormen......................................................................................................................................7
Andere vormen.....................................................................................................................................................7
Type 1....................................................................................................................................................................8
LADA.................................................................................................................................................................8
Genetisch..........................................................................................................................................................8
Pathogenese.....................................................................................................................................................8
Symptomen.......................................................................................................................................................9
Verschillen type 1 en type 2..................................................................................................................................9
Type 2....................................................................................................................................................................9
8 features (pathogenese)..................................................................................................................................9
Samengevatte kenmerken type 2...................................................................................................................10
2 Diabetes: acute complicaties..................................................................................................................... 11
Hypoglycemie.....................................................................................................................................................11
Symptomen.....................................................................................................................................................11
Soorten coma’s...............................................................................................................................................11
Ernst................................................................................................................................................................12
Risico...............................................................................................................................................................12
Prevalentie bij antidiabetica...........................................................................................................................12
Effecten...........................................................................................................................................................12
Counterregulatoire mechanismes..................................................................................................................13
Behandeling....................................................................................................................................................13
Diabetische keto-acidotische coma....................................................................................................................14
Wanneer ketonen monitoren?.......................................................................................................................14
DKA metabole gevolgen.................................................................................................................................15
Symptomen ernstige decompensatie.............................................................................................................15
Urgentiemaatregelen......................................................................................................................................15
Complicaties...................................................................................................................................................15
Opvolging........................................................................................................................................................16
Euglycemische keto-acidose bij SGLT-2 inhibitoren............................................................................................16
Euglycemische ketoacidose - waarom ketonen?............................................................................................16
SGLT2-i in type 1 en 2.....................................................................................................................................16
Wanneer ketonen monitoren.........................................................................................................................16
SGLT2-1 in type 1............................................................................................................................................17
Hyperosmolair non-ketotisch hyperglycemisch coma (dehydratatie)................................................................17
Hyperglycemisch coma...................................................................................................................................17
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