Exam (elaborations)
UNE Biochemistry Final Exam Questions and Answers 100% Pass
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UNE Biochemistry
UNE Biochemistry Final Exam
Questions and Answers 100% Pass
What are the direct products of Beta Oxidation? - NADH
FADH2
Acetyl CoA
What does Acetyl CoA get used for - ketogenesis
allosterically activates Pyruvate Carboxylase
An 11yo girl is brought into the emergency department by her fathe...
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UNE Biochemistry Final Exam
Questions and Answers 100% Pass
What are the direct products of Beta Oxidation? - ✔✔NADH
FADH2
Acetyl CoA
What does Acetyl CoA get used for - ✔✔ketogenesis
allosterically activates Pyruvate Carboxylase
An 11yo girl is brought into the emergency department by her father. He reports that she has recently
been very thirsty and needing to make frequent trips to the bathroom. At her soccer game today, she
complained of lightheadedness and symptoms did not resolve even after drinking a power beverage. A
rapid dipstick test revealed glucose in her urine and further diagnostics indicate with a diagnosis of Type
1 Diabetes. Evaluation of the liver would indicate an increased amount of which of the following
processes? - ✔✔Ketogenesis
What is the role of adipose in metabolism? - ✔✔storage of triacyglycerols
appetite regulation, coagulation, immunity, reproduction
A 5yo female is brought into the ED by her mother. She is a type 1 diabetic and has not taken her insulin
while away at a day camp. The child is unresponsive. Which of the following enzymes is phosphorylated
and active under these conditions? - ✔✔hormone sensitive lipase
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,An individual goes to bed around 8 pm and doesn't wake up until 9 am the next morning. During this
time, which of the following is the primary oxidizable substrate in the skeletal muscle? - ✔✔free fatty
acids
An individual is on a hunger strike and has not eaten in 13 days. Which of the following best describes
their metabolic state? - ✔✔The brain will be preferentially oxidizing ketones
In the fasted state, fatty acyl-CoAs are transported across the mitochondrial membrane. The transport of
fatty acids via carnitine palmitoyl transferase I (CPTI) can be directly inhibited by which of the following
compounds? - ✔✔Malonyl CoA
Under fasting conditions (ratio of insulin to glucagon <1), elevated glucagon will activate which of the
following enzymes? - ✔✔Hormone Sensitive Lipase
A well, 2-year-old girl presents to the clinic with symptoms of a viral illness. Her parents report she has
had bouts of vomiting and diarrhea over the last 24 hours. This morning they could barely wake her from
her crib and she was very weak. Laboratory tests show low blood glucose (hypoglycemia) and elevated
liver enzymes. There are no ketones present in her urine. The child is hospitalized and glucose is
administered by I.V. Additional laboratory analysis showed elevated medium-chain fatty acyl carnitines
in blood and 6-8 carbon dicarboxylic acids in the urine. Which of the following abnormalities is the most
likely diagnosis for this child? - ✔✔Defect of medium-chain acyl-dehydrogenase
A 22-year-old woman engaging in a political protest goes on a hunger strike on a prominent corner in a
city park. She refuses all offers of food except for water through the first 2 weeks. Under these conditions
there is a decreased reliance on which of the following pathways for fuel? - ✔✔Gluconeogenesis
ATP can be generated by many metabolic pathways in the body. Which of the following processes
generates the most ATP? - ✔✔Fatty acid beta oxidation
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, In liver, which of the following key inhibitory events ensures that newly synthesized palmitoyl-CoA is
not immediately oxidized? - ✔✔Inhibition of carnitine-palmitoyl transferase-I (CPT-I) by malonyl-CoA.
An increase in the ratio of insulin to glucagon will increase which of the following enzymes? -
✔✔hormone sensitive lipase decreases
acetyl CoA carboxylase increases
Phosphofructokinase 2 increases
glycogen synthase increases
NADPH is essential for fatty acid synthesis and can be generated by which two enzymes? (+ indicates
NADPH can be produced by the enzyme; - indicates the enzyme does not produce NAPDH) For G6P
Dehydrogenase, Malic Enzyme, and Pyruvate Dehydrogenase Complex - ✔✔+, +, -
A defect in the thioesterase subunit of fatty acid synthase would impair which of the following activities
of the enzyme complex? - ✔✔Liberation of newly assembled palmitate from the enzyme
Malate can be converted to pyruvate in the cytosol. Which of the following compounds is directly
generated in this conversion and is essential for fatty acid synthesis? - ✔✔NADPH
Which of the following enzymes is correctly paired with its allosteric inhibitor? - ✔✔Acetyl-CoA
carboxylase: palmitoyl-CoA
An increase in the ratio of insulin to glucagon leads to which of the following metabolic shifts? -
✔✔Acetyl-CoA carboxylase will become dephosphorylated and active
In the case of a deficiency of biotin, which of the following enzymes required for fatty acid metabolism
will be impaired? - ✔✔Acetyl-CoA carboxylase
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