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Drugs and the brain

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Unit 2 lecture 6 of NEU 101, goes in-depth on all drugs covered for the exam as well as what they do, antagonist or agonist, direct or indirect etc.

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  • January 11, 2025
  • 5
  • 2024/2025
  • Class notes
  • Shannon eaton
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Drugs & The Brain
Pharmacology
study of the interaction between chemicals and living organisms

Neuropharmacology: Study of how chemicals affect the brain

Toxicology: study of harmful effects of drugs & toxins

Pharmacodynamics: how drugs affect the body

Pharmacokinetics = how the body affects drugs


Notes in receptors
One receptor can have many subunits

neurotransmitter

other substance sites as well


Binding
Lock & key: neurotransmitter fits into receptor like a lock & key

Induced fit: receptors & neurotransmitters grab each other

Bind —> shape changing


Drugs
Can be prescribed or recreationally

licit: Legal

illicit: Illegal

Drugs are not inherently good or bad, how it is used (societal standard)
determines good and badness

Most psychoactive substances have more than 1 mechanism of action

Drugs feel good: DA “reward” area



Drugs & The Brain 1

, tegmentum to nucleus succumbos

Rats will work to stimulate this until they die


Agonists
Mimics effects of given neurotransmitter

“the helper”

“lock pick”


Antagonist
Dampens effects of neurotransmitter

“The Vilans”

break or block lock

Direct agonist & antagonist
agonist: binds to receptor & recreates action

Antagonist: goes into receptor & blocks neurotransmitter from being able to
act


Acetylcholine
Nicotine: Agonist, mimicking it

Nicotinic receptors (ionotropic)

Muscarine: direct agonist

muscarinic receptors (metabotropic)

Curare: antagonist

Nicotinic receptors (ionotropic)

make muscles stop working, causes paralysis death

Atropine (belladonna): antagonist

Muscarinic receptor



Drugs & The Brain 2

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