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samenvatting geneesmiddelentoxiciteit met bijwerkingen per geneesmiddel(klasse) $11.22
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samenvatting geneesmiddelentoxiciteit met bijwerkingen per geneesmiddel(klasse)

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samenvatting geneesmiddelentoxiciteit + bijwerkingen per geneesmiddel (2e mastere farmaceutische wetenschappen)

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  • January 16, 2025
  • 8
  • 2024/2025
  • Summary
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diphenhydramine → sedatie via on target effect thv CZS H2

statine → spierpijn + rhabdomyolyse via on target effect thv spieren H2

terfenadine → aritmieën via off target effect d. hERG inhib H2

thalidomide → aangeboren hartafwijking H17

→ afwijkingen thv ledematen via vasculaire disrupties/ intra uteriene contracties, via off
target effect (teratogeniciteit) H2, H17

cefaclor → serumziekte (jeuk, gewrichtspijn) hypersensitiviteit type III H2

PPI → SCLE (~lupus) via auto immuniteit H2

ACE-inhib → angio-oedeem (d. VD), hoest, inflammatie, ↑vascul permeab (C.I astma) H3, H12

→ jeuk via ↑ bradykinine H19

NSAID (COX-I) → AERD (C.I astma) H3, H12
(vb. aspirine)

→ uitlokken/verslechteren psoriasis H4 (inhib °PG, meer LT ook thv huid)
(vb. piroxicam)

→ fotosensitiviteit via decarboxylatie COOH H5
(vb. ketoprofen (~ octocrylene, fenofibraat)

→ agranulocytose H14

salicylaten (ASA) + → hypersensitiviteit → AERD (C.I astma) H3, H12
NSAIDS
→ allergie → rash + angio-oedeem H3

→ uitlokken/verslechteren psoriasis H4 (inhib °PG, meer LT ook thv huid)

β-blokkers → uitlokken/verslechteren psoriasis H4 (door epidermale cellulaire turnover, beta2rec,
vnl niet selectieve)

→ bronchoconstrictie (C.I astma) via off target effect H2, H12

β2 agonisten → HxR↑ via off target effect H2

→ << orofaciale left (teratogeniciteit) H17

allopurinol → DRESS via °oxypurinol (actieve metaboliet) H4

diuretica → hypersensitiviteits-/ allergie reactie via sulfamoyl groep H3

→ fotosensitiviteit via dissociatie Cl-groep H5

→ ototoxiciteit via verstoring homeostase endocochleaire vloeistof H16

diuretica + Li → Li toxiciteit (GIprob + verwardheid) H8

, lisdiuretica → hypersensitiviteits-/ allergie reactie via sulfamoyl groep H3

→ fotosensitiviteit H5

→ ototoxiciteit via verstoring homeostase endocochleaire vloeistof H16

thiazide → hypersensitiviteits-/ allergie reactie via sulfamoyl groep H3

→ fotosensitiviteit H5

→ ototoxiciteit via verstoring homeostase endocochleaire vloeistof H16

ARB → hypersensitiviteit H3: angio-oedeem (nt combineren met ACE-I !!)

salicylaten + quinine → ototoxiciteit via ↓cochleaire bloedflow H16

AB → being floxed (pees aantasting, duizelig, hallucinaties, QT↑) H2
(vb. fluoroquinolones)

→ hypersensitiviteits-/ allergie reactie (mogelijk via sulfamoyl groep → SJS) H3
(vb. penicilines, carbapenem, cephalosporines)

→ fotosensitiviteit H5​
(vb. tetracyclines, fluoroquinolones, sulfonamiden)

→ epileptische aanvallen H6 ​
(vb. fluoroquinolones, carbapenems, cephalosporines, penicilline)

→ levertoxiciteit (via hepatocellulaire cytotoxische schade) H10 ​
(vb. amoxicilline + clavulaanzuur: ‘amoxiclav’)

→ agranulocytose H14

→ koorts d. hypersensitiviteitsreactie H15​
(vb. penicilines, cephalosporines)

→ koorts d. serumziekte H15
(vb. amoxiciline bij kinderen)

→ ototoxiciteit via oxidatieve schade H16
(vb. aminoglycosides)

→ jeuk H19

penicillines, → allergie (kruisreact igv core allergie) H3
cefalosporines,
carbapenems

tetracyclines → hypersensitiviteit nl serumsickness + lupus achtige sympt H3
(bv. minocycline)

vancomycine (IV) → hypersensitiviteit nl red man syndrome (veralgemeende roodheid) H3

aminoglycosides → ototoxiciteit via oxidatieve schade H16

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