Summary
Samenvatting ALLE geneesmiddelen farmacologie
- Course
- Institution
samenvatting van alle klassen geneesmiddelen, inclusief bijwerkingen, contra-indicaties etc, gesorteerd per indicatie.
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Stofnaam Klasse Gebruik Bijwerkingen Interacties CIDEEL 1
Amikacine Aminoglycoside AB TDM!!! Nefrotoxiciteit Cave nierinsuf (RK)
Kanamycine Im of iv Ototoxiciteit Zwangerschap
Gentamycine NO SWITCH Curare effect: NM blok Myasthenia gravis
Paromomycine
Tabramycine
Spectinomycine
Streptomycine
Doxycycline Tetracyclines (AB) Cave inname met Bruine verkleuring Kinderen tot 8 j
minocycline melkproducten, al, tanden Zwangeren +
ca, mg Inhibitie groei lactatie
… (groeikraakbeenschijve
n)
Fotosensitiviteit
Vertigo
Wijziging intestinale
flora
GI irritatie (NB,
oesofagitis,
slokdarmulcera)
Hepatotoxiciteit
nefrotoxiciteit
Thromboflebitis (iv)
Benigne intracraniële
hypertensie
Chloramfenicol Aplastische anemie
Gestoorde rijping RBC
in beenmerg
Grey baby syndrome
Eryhtromycine Macrolide AB GI (anorexie, NBD) Inhibitor CYP3A4 CV belast
(gastroprokinetisch) cave CYP3A4
QT!!!! inhibitoren
TDP Cave QT
verlengende f
Clarithromycine Macrolide AB GI (anorexie, NBD) Inhibitor CYP3A4, P- CV belast
QT: TDP gp
Cave CYP3A4
inhibitoren
, Cave QT
verlengende f
azithromycine Macrolide AB GI (anorexie, NBD) Inhibitor P-gp CV belast
QT: TDP Cave CYP3A4
inhibitoren
Cave QT
verlengende f
Clindamycine AB Entercolitis door
overgroei c difficile
metronidazole R/
Linezolid AB Grampositieve oa Thrombocytopenie IMAO: tyramine, epilepsie
vancomycine Perifere en optische adrenerge of
resistente neuropathie (> 28d) serotoninerge
enterokokken en ¯ convulsiedrempel agonist
MRSA hypertensieve
crisis
serotoninesyndroom
sulfamiden Vnl lokaal Kruisallergie met
Systemisch in - KZA inhibitoren
combinatie - lisdiuretica
- thiaziden
- bep orale
antidiabetica
Co-trimoxazol Sulfamide, Allergische reacties: Kruisallergie met
sulfamethoxazol + - huiderupties hypoglykemiërende
trimethoprim - hematologische afwijk sulfamiden
- serumziekte
DRESS syndroom
Stevens johnson en
lyell syndroom
Hematologische Interferentie Zwangerschap (T)
afwijkingen metabolisme FZ
hyerpkaliemie
Ciprofloxacine chinolonen GI: NBD Kationen Zwangerschap +
Levofloxacine CZS ¯absorptie oraal lactatie
Moxifloxacine - hoofdpijn CYP1A2 inhibitoren Kinderen < 18j
- slapeloos ( theofylline) Leverziekte
- depressie CV belast
, - eplepsie Corticosteroïden
QT verlenging!!! Epilepsie, depressie
Artritis klachten
Beschadigd
groeikraakbeen
Ruptuur achillespees
Resistentie
hepatotoxiciteit
Penicilline Inhibitie Zeer lage toxiciteit Cave nierinsuf (RK)
celwandsynthese Overgevoeligheid/
allergie
kruisovergevoeligheid
Vancomycine Nefrotoxiciteit Cave nierinsuf (RK)
(teicoplanine) Ototoxiciteit
Red man / red neck
syndroom
(flushing – H
vrijzetting)
Metronidazole Nitro- Hoofdpijn Alcohol disulfiram
imidazoolderivaat Nausea effect
GEEN azole Droge mond Inhibitor CYP2C9 (
antimycotica Metaalsmaak warfarine, fenytoïne)
Meropenem Carbapenem AB ¯ convulsiedrempel Valproaat (¯)
Imipenem
Rifampicine Overgevoeligheid Inductor CYP1A2,
(intermit) CYP2C9, CYP2C19,
- koorts, hoofdpijn, CYP2D6, CYP3A4, P-
spierpijn, malaise gp
- trombocytopenie Hormonale
- nierinsuf anticonceptiva
Oranjerood verkleuring Immuunsuppressiva
secreten - ciclosporine
- tacrolimus
- sirolimus
- everolimus
Anti-retrovirale
middelen
VKA
Fluconazol Azoolderivaten AB Dermatofyten, Hepatotoxiciteit Inhibitor CYP2C9 en
, schimmels QT verlenging!!! CYP3A4
Versterken VKA
Itraconazol Azoolderivaten AB Dermatofyten, Hepatotoxiciteit Substraat en
schimmels QT verlenging!!! inhibitor CYP3A4
Inhibitor P-gp
Versterken VKA
ketoconazol Azoolderivaten AB Dermatofyten, Hepatotoxiciteit Inhibitor CYP3A4 en
schimmels QT verlenging!!! Pgp
Versterken VKA
Posaconazol Azoolderivaten AB Dermatofyten, Hepatotoxiciteit Inhibitor CYP3A4 en
schimmels QT verlenging!!! P-gp
Versterken VKA
Miconazol Azoolderivaten AB Dermatofyten, Hepatotoxiciteit Inhibitor CYP2C9
schimmels QT verlenging!!! Versterken VKA
Voriconazol Azoolderivaten AB Dermatofyten, Hepatotoxiciteit Inhibitor CYP2C9,
schimmels QT verlenging!!! CYP2C19, CYP3A4
Versterken VKA
Dextromethorfa Hoest Hoge dosis: centrale Substraat CYP2D6
n depressie Serotoninerge med
serotoninesyndroom
DEEL 2
Acetylcholine muscarineR agonist Miosis operatie Cave astma
Pilocarpine muscarineR agonist Mioticum (lokaal) Centrale effecten Cave astma
monddroogte -
(sjorgen)
Gesloten hoek
glaucoom
carbachol musarineR agonist Miosis operatie Cave astma
Gesloten hoek
glaucoom
Bupropion nicotineR agonist
Neostigmine Reversibele Postop blaas-maag- Cave astma
Pyridostigmine cholinesterase darm-atonie
inhibitoren Myasthenia gravis
Fysostigmine Reversibele Gesloten hoek Centrale effecten Cave astma
cholinesterase glaucoom - angst excitatie
inhibitoren Antidotum intox - zenuwachtigheid
atropine
Atropine musarineR Anesthesie Visusstoornissen Glaucoom !!
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