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Cell Biology & Neuroscience Notes

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A comprehensive guide spanning over 100 pages on Cell Biology and Neuroscience, designed to cater to both enthusiasts and those seeking to strengthen their understanding of these complex subjects. Explore the detailed Table of Contents to ensure it covers the topics you’re looking for.

Last document update: 2 days ago

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  • January 16, 2025
  • January 16, 2025
  • 118
  • 2024/2025
  • Class notes
  • Subathra p
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CELL BIOLOGY AND
NEUROSCIENCE NOTES
ATHENA HOUSE

, CONTENTSTABLE OF CONTENTS
Cell Types and Subcelluar Structures
5
Cell Concept
Classification of Cells
Eukaryotic Cell Organisation
Specialised Cellular Processes


Cells in their Environment 14
Cellular Life Origins
Cellular specilisation & Multicellularity
Cellular & Subcellular Pathogens


Cytoskeleton 17
Microfilaments, Intermediate Filaments, and Microtubules
Actin & Myosin
Properties of Tubulin & Microtubules
Tubulin Polymerisation & Factors affecting It
Cytoskeleton: Role, Structure, Shape & Motility
Motor Proteins: Kinesin & Dynein


Cell Adhesion and Junctional Complexes
Cell-Cell Adhesion
24
Cell-Matrix Adhesion
Extracellular Matrix


Neurons and Glia
Major Classes of Neurones
Convergence and Divergence in Neural Networks
29
PNS & CNS Glial Cells
Function of Glial Cells (Nervous System)


Neurons and Neuronal Communication
Neuron Structure & Function
39
Resting Membrane Potential
Acting Potential & Neuronal Communication


Membranes and Membrane Transport
Cell Membranes
44
Concentration of Ions Across Plasma Membranes
Partition Coefficient, Transport Kinetics, Uniport, Symort & Antiport
Solutes Crossing Biomembranes
Solute Transporters

, CONTENTSTABLE OF CONTENTS

Neurons and Neuronal Communication: Synapses and synaptic transmission 47
Synapse: Structure & Function
Communication Across Synapses


Organisation of the nervous system 49
The Nervous System: CNS & PNS
Nervous System: Anatomical Subdivisions
Ventricular System of the Brain
Meningeal Layers surrounding the Brain & Spinal Cord

54
Cell Cycle
Prokaryotic Cell Cycle
Eukaryotic Cell Cycle Phases
Coordination & Control of the Cell Cycle
Eukaryotic Cell Cycle: Cyclin & Cyclin- Dependent Kinase Complexes


Cell Signalling 62
Functions of cells in Multicellular Organisms
Modes of Signalling + examples: Endocrine, Paracrine, Neuronal & Contact Dependent
GTP-binding protein-coupled Receptors (pathways activated)
Roles of Protein Kinases in Cell Signalling


Endocytosis and Vesicle Trafficking 67
Overview
Types of Cellular uptake: Phagocytosis, Macropinocytosis, Clathrin-Mediated Endicytosis,
Non-Clathrin-Mediated Endocytosis (Caveolin-mediated endocytosis)
Differentiating between Clathrin-mediated & Non-Clathrin-mediated Endocytosis
Mechanisms of Phagocytosis & CME
Endocytic Pathway Compartments


Protein Sorting and Trafficking 76
Cell Compartments & Topology
Signal Sequences in Protein Targeting
Protein Modifications in the Endoplasmic Reticulum & Golgi Apparatus
Modes of Transport


Apoptosis, Necrosis and Excitotoxicity 84
Cell Death: Apoptosis, Necrosis & Excitotoxicity
Apoptosis: Essential for Development
Conservation of Apoptosis Across Eukaryotes
Excitotoxicity: Neural-Specific cell death

, CONTENTSTABLE OF CONTENTS
93
Development of Multicellular Organisms
Germ Cell Formation in Development
Meosis and its role in gamete formation
Fertilisation in mammals
Asexual Reproduction in Hydra
Parthenogenesis

99
Stem Cells
Essential Characteristics of Stem Cells
Types of Stem Cells
Methodologies in identification of stem cells
Stem Cell Niches
Induced Plutipotent Stem Cells
Stem celks in research and Therapy

105
The Immune System
Structure & Function of the Immune System
Cellular Components of the Immune System
Innate & Adaptive Immune Responses
Action of Immune Components in Specific Tissues

113
Immunology II: Self vs Non-Self recognition and Neuroimmunology
How the immune System recognises a wide range of antigens
Principles of Self vs Non-self Recognition & Autoimmunity
Immune Privilege
Neurological Diseases with immune origin: Multiple Sclerosis, Parkinson’s Disease, Alzheimer’s
Disease

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