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Summary Topic 2 Cystic Fibrosis $3.76
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Summary Topic 2 Cystic Fibrosis

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Edexcel Biology Topic 2 Cystic Fibrosis, Mucus Production, CFTR protein.

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  • January 19, 2025
  • 6
  • 2022/2023
  • Summary
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Cystic Fibrosis


Mucus -
When there is excess water in the mucus


regulation
S.I units
. Sodium
1 ions are pumped out of the epithelial cell via basal
membrane into the tissue fluid vic active transport
.
Reduces concentration of sodium ions in .
cell


2
. Concentration
gradient formed between mucus and inside cell.
Facilitated
Sodium
diffusion of ions via a channel protein
in the apical membrane into the epithelial cell reduces ions
Concentration in the Mucus




. Positive
3 tissue
fluid. Electrical gradient
charge resides in the .




Chloride Cli down the
ions , move
gradient to the tissue
fluid
4. More
solute in the tissue fluid which decrease the water

potential in tissue fluid
. Vic Osmosis water
diffuses out
of the cell
down the concentration
gradient lowering the water potential
in the cell


3 .
Higher water potential in the mucus due to lower solutes
means via osmosis water
diffuses from murus into the

epithelial cell -




-
Mucus becomes more viscous

, S.I units

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