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LPMS Exam Questions And Correct Answers 100% Verified. The primary site of hematopoiesis changes location during development. In the fetus, by the eighth month of intrauterine life, the primary site of hematopoiesis is in which of the following locations? A.bone marrow B.liver C.spleen D.th...

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  • January 21, 2025
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  • 2024/2025
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LPMS Exam Questions And Correct
Answers 100% Verified.



The primary site of hematopoiesis changes location during development. In the fetus, by the
eighth month of intrauterine life, the primary site of hematopoiesis is in which of the following
locations?
A.bone marrow
B.liver
C.spleen
D.thymus

E.yolk sac - Answer✔A. bone marrow
At what age does the thymus reach its maximal size?
A.During the first year of life
B.Teenage years (puberty)
C.Between 40 and 50 years of age

D.After 70 years of age - Answer✔B. Teenage years (puberty)
Which one of the following is an attribute of the innate, rather than the adaptive (acquired),
arm of our host defenses?
A.Is highly specific in its response to bacteria
B.Responds to viruses and fungi, but not bacteria
C.Exhibits memory following exposure to bacteria
D.Is part of our host defense against bacteria but not against fungi

E.Is as effective the first time it is exposed to bacteria as it is subsequent times - Answer✔E. Is
as effective the first time it is exposed to bacteria as it is subsequent times
A 4-year-old boy is referred to a specialist for the diagnosis of a possible immunologic problem.
The child has extremely elevated white blood cell counts, with a profound lymphocytosis. A

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biopsy performed on a cervical lymph node reveals extreme hypocellularity in both cortical and
paracortical areas. Absence of which of the following leukocyte surface molecules could result
in this clinical pictures?
A.Addressins
B.Chemokines
C.Immunoglobulin
D.Integrins

E.L-selectins - Answer✔4E
L-selectins are the molecules found on the surfaces of lymphocytes that mediate their binding
to the high endothelial venules of hymph nodes. This is the means by which lymphocytes enter
lymph nodes; without these molecules, they would be unable to leave the blood. Thus they
would rise in the blood to extreme levels and be absent form their appropriate areas in the
secondary lymphoid organs.
About spleen, which of the following statement is NOT correct?
A.It filters antigens out of the blood.
B.The periarteriolar lymphoid sheath (PALS) is rich in T cells.
C.It contains germinal centers.
D.It functions to remove old and defective red blood cells.

E.Lymphatic vessels draining the tissue spaces enter the spleen. - Answer✔E. Lymphatic vessels
draining the tissue spaces enter the spleen.
Which of the following differentiates an antigen from an immunogen?
A.An antigen is a foreign molecule
B.An antigen can cause the production of antibodies
C.An antigen does not always elicit an immune response
D.Antigens are usually proteins or polysaccharides

E.Antigens are capable of being bound by immunologic receptors - Answer✔C. An antigen does
not always elicit an immune response
*Which of the following is NOT true regarding effective immunogens?
A.Foreign to the host
B.Fairly large (molecular weight > 6000)
C.Chemically complex (e.g. proteins made of many nucleotide bases)


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D.Requires a carrier-conjugate to cause the generation of antibodies - Answer✔D. Requires a
carrier-conjugate to cause the generation of antibodies
Which of the following best describes penicillin, a hapten?
A.Large in size and can induce an immune response alone
B.Large in size and needs to be coupled to induce an immune response
C.Small in size and can induce an immune response alone

D.Small in size and needs to be coupled to induce an immune response - Answer✔D. Small in
size and needs to be coupled to induce an immune response

Hapten - Answer✔small molecule that has to bind to a larger molecule to form an antigen

Isograft - Answer✔use of identical twin's tissue
*A 28-year-old man was brought into court for nonpayment of child support. A 20-year-old
woman insists that he is the father of her child. The court suggests before hearing the paternity
case that various genetic tests be performed on the man, woman, and child. One of the sets of
tests was for genetic immunoglobulin identification. Which immunoglobulin marker would be
useful in this case?
A.Allotype
B.Idiotype
C.IgA2
D.IgM

E.Isotype - Answer✔A. individuals of the same species
*A 30-year-old woman comes to the physician because of a fever of 38.4°C and a diffuse
macular rash on her torso. Her blood pressure is 91/51 mm Hg. The physician obtains a culture
from her vagina that shows catalase-positive, gram-positive cocci. Over the next few days, the
rash on her torso desquamates. Which of the following organisms is most likely responsible for
this patient's symptoms?
A.Actinomyces israelii
B.Clostridium perfringens
C.Proteus mirabilis
D.Staphylococcus aureus

E.Streptococcus pyogenes - Answer✔D
Staphylococcus aureus is a gram-positive, catalase-positive coccus. It produces a superantigen
called toxic shock syndrome toxin. The toxin causes a disease characterized by fever,

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hypotension, and a diffuse macular rash that desquamates after a few days.Answer A is
incorrect. Actinomyces israelii is a filamentous organism that is part of the normal flora of the
mouth and gastrointestinal tract. It does not cause toxic shock syndrome.Answer B is incorrect.
Clostridium perfringens is the organism responsible for the development of gas gangrene. This
organism is associated with contaminated wounds and not with toxic shock syndrome.Answer C
is incorrect. Proteus mirabilis is a common cause of urinary tract infections and is not
associated with toxic shock syndrome.Answer E is incorrect. Streptococcus pyogenes, a gram-
positive coccus, can also cause toxic shock syndrome. Unlike S. aureus, it is catalase-negative.
A student has a genetic defect and cannot produce the J chain which is important in the
structure of some immunoglobulin molecules. Which of the following will most likely be
observed in this individual?
A.a decrease in mature B cells
B.a decrease in mature T lymphocytes
C.a decrease in serum IgM
D.an increase in IgA in the intestine

E.an increase in serum IgM and decrease in IgE - Answer✔C. a decrease in serum IgM
*An antiserum containing IgG directed against a large protein antigen is treated with the
enzyme pepsin. After refrigeration overnight, the resulting supernatant is mixed with the
protein antigen. This final mixture is most likely to do which of the following?
A.Agglutinate the antigen
B.Bind complement
C.Bind phagocytic cells
D.Lose cross-linking ability

E.Precipitate the antigen - Answer✔E
IgG and F(ab')2 fragments both have a valence of 2 and can bridge between antigens. Soluble
antigens will them precipitate. Particulate antigens (e.g. RBC) will then clump together.
(agglutinate). Supernatant includes the soluble proteins (soluble antigen).
A 24-year-old primigravid woman develops an acute infection with Toxoplasma gondii during
her first trimester of pregnancy. Blood-borne antigens of the parasite spread throughout the
fetal circulation. The patient later delivers a full-term baby boy with no apparent sighs of in
utero infection. A parasite-specific ELISA for which of the following immunoglobulin isotypes
would be the most appropriate test to diagnose acute infection in the neonate?
A.IgA
B.IgE


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