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N 5315 ADVANCED PATHO HEMATOLOGIC MODULE 4 EXAM QUESTIONS AND CORRECT DETAILED ANSWERS (VERIFIED ANSWERS) ||ALREADY GRADED A+||NEWEST VERSION $15.99
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N 5315 ADVANCED PATHO HEMATOLOGIC MODULE 4 EXAM QUESTIONS AND CORRECT DETAILED ANSWERS (VERIFIED ANSWERS) ||ALREADY GRADED A+||NEWEST VERSION
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Quiz: What is the peripheral zone of platelet? Ans: Outermost layer. Made of phospholipids. Contains many receptors responsible for platelet adhesion and aggregation Quiz: What is the sol-gel of the platelet Ans: It is the outermost layer made of possible if it contains many receptors respon...

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  • January 24, 2025
  • 62
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • n 5315 advanced patho hematologic module 4 exam q

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  • N 5315 ADVANCED PATHO HEMATOLOGIC
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N 5315 ADVANCED PATHO HEMATOLOGIC
MODULE 4 EXAM QUESTIONS AND CORRECT
DETAILED ANSWERS (VERIFIED ANSWERS)
||ALREADY GRADED A+||NEWEST VERSION
Quiz: What is the peripheral zone of platelet?

Ans: Outermost layer. Made of phospholipids. Contains many receptors

responsible for platelet adhesion and aggregation




Quiz: What is the sol-gel of the platelet

Ans: It is the outermost layer made of possible if it contains many receptors

responsible for platelet adhesion and aggregation




Quiz: What is the organelle zone of platelets

Ans: Innermost layer contains calcium dense granules and alpha granules




Quiz: What are the four phases of platelet plug formation?

Ans: Activation, adherence, aggregation, and secretion




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Quiz: What is the first step or phase of platelet plug formation and

explain

Ans: Activation is the first step. In physiological states. Platelets circulate

without adhering to the intact endothelium. An injury to the endothelium

exposes thev WF, fibronectin, collagen and from thrombospondin.. Collagen is a

potent activator and when the sub endothelial collagen is exposed by an injury.

The platelets become charged AKA activated. Platelets and become aware of

the injury and undergo a shape change that increases their ability to adhere to

the site of injury.




Quiz: The second step in platelet plug formation is

Ans: Adherence is a process by which platelets attached to the injured

endothelium. Adherence begins with the vWF. Circulating vWF binds to the

exposed subendothelial collagen and to the GP Ib/IX/V receptors on circulating

platelets. Collagen then binds with the GP VI receptor. The binding of collagen

with the GP VI receptor results in the activation of the GPIIb/IIIa and GPIa/IIa

receptors. vWF then binds with the GPIIb/IIIa receptors and collagen further

binds with the GPIa/IIa receptors. This collective binding anchors the platelets in

place




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Quiz: The third step in platelet plaque formation is

Ans: Aggregation- is the process by which platelets bind to one other. There

are multiple GPIIb/IIIa receptors on one platelet and when activated (as

described above) they have a greater affinity for fibrinogen. Fibrinogen is able to

bind to two GPIIb/IIIa receptors simultaneously and thereby bind platelets

together




Quiz: The fourth step in platelet plug formation is

Ans: Secretion- during this phase the platelet granules release their contents.

a. ADP- enhances adhesion, activates platelets and recruits platelets

b. Serotonin recruits platelets.

c. Fibronectin and thrombospondin are proteins which stabilize platelets that

are adhered to the site of injury.

d. Thromboxane A2- is a product of the arachidonic acid pathway but is stored

inside the platelet too. It causes vasoconstriction and enhances platelet

aggregation.

e. Growth factors promote tissue repair however they have a role in the

development of atherosclerosis.




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Quiz: The final step in platelet plug formation

Ans: The platelet plug is stabilized by fibrin and XIIIa which are the end

products of the coagulation cascade.




Quiz: What is the extrinsic pathway arms of the coagulation cascade




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