Antistolling
Medicatie Groep Gebruikt voor Werkingsmechanisme Bijwerkingen Interacties Contra-indicaties
Dabigatran DOAC o.a. Atriumflutter Antistolling Niet goed zichtbaar of het NSAID’s (Naproxen, Slechte nierfunctie
Rivaroxaban Veneuze problemen Directe trombine remmer factor II wel/niet is gebruikt ibuprofen, diclofenac) (lager doseren)
Apixaban (atriumfibrilleren, Direct invloed op fibrinogen
Endoxaban longembolie)
Secundaire hemostase
Acencoumarol/ Vit K-antagonist o.a. Atriumflutter Antistolling 3 dagen tot effect NSAID’s (Naproxen,
fenprocoumon veneuze trombose Remmen stollingsfactoren IX, X, II, VII Oppassen met dieet: Vit-K ibuprofen, diclofenac)
Secundaire hemostase fibrinogeen minder omgezet in fibrine remt het medicijn Miconazol
verminderde stollingscapaciteit plasmaspiegel
acenocoumarol stijgt
doorgeschoten INR met
grote kans op bloeding
DOAC
Heparine LMWH (heparine) Veneuze problemen Antistolling Maag-darm klachten, NSAID’s (Naproxen,
Nadroparine Secundaire hemostase Activatie anti-trombine III omzetting hoofdpijn ibuprofen, diclofenac)
fibrinogeen fibrine geremd Vit-K antagonisten
Tranexaminezuur 5% Antifibrinolytica Bloeding, gevaar van Zorgt ervoor dat de fibrinedraden die worden Maagdarmklachten
200 ml bloeding gevormd, niet worden afgebroken
Remmen plasminogeen
Acetylsalicylzuur TAR (salicylaten) Na MI, na TIA, AP Trombocytenaggregatieremmer Langer bloeden NSAID’s (Naproxen, Astma-aanval,
(aspirine) Arteriële problemen COX remmers remt prostaglandinen maag Gastro-intestinaal ibuprofen, diclofenac) ernstige hartfalen
Primaire hemostase minder goed beschermd bloedverlies Corticosteroïden, SSRI’s
Pijnstiller Remt Tromboxanen Maagzweren (ulcera) (antidepressiva)
Alcohol
Clopidogrel TAR (salicylaten) Na TIA/CVA Trombocytenaggregatieremmer Langer bloeden NSAID’s (Naproxen, Ernstige
Arteriële problemen Plavix Gastro-intestinaal ibuprofen, diclofenac) leverfunctiestorniss
Primaire hemostase ADP-receptor blokkers bloedverlies Corticosteroïden, SSRI’s en
(antidepressiva)
Carbasalaatcalcium TAR (salicylaten) Arteriële problemen Trombocytenaggregatieremmer Langer bloeden NSAID’s (Naproxen,
Dipyridamol Primaire hemostase Gastro-intestinaal ibuprofen, diclofenac)
Prasugrel bloedverlies Corticosteroïden, SSRI’s
Ticagrelor (antidepressiva)
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