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Samenvatting Mannelijk geslachtsstelsel - stelselmatige weefselleer
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Mannelijk geslachtsstelsel1 TESTIS EN AFVOERWEGEN
Testes/testis/testikels/teelballen: ontwikkelt i/d buikholte en daalt af in het scrotum
1.1 SCROTUM
= balzak
Epidermis:
- EP: meerlagig verhoornd plaveisel
- Basale cellen ++ pigment
Dermis:
- Dik, haren, talgklieren, zweetklieren
- Tunica dartos: ++ elastine en gladde spieren (= musculo-elastische laag)
Verschillende bladen rond teelbal:
- M. cremaster
- Fascia
- Tunica vaginalis: pariëtaal en visceraal blad
*hydrocoele: opstapeling sereus vocht zwellen v/d
teelbal
- Tunica albuginea: BW kapsel
- Tunica vasculosa: gevasculariseerde zone v/d TA, ligt
tegen tubuli seminiferi
1.2 TUBULI SEMINIFERI
= zaadbuisjes
tubuli recti buisvormig netwerk = rete testis
Ontwikkeling:
- Kinderjaren (2-8 jaar): celstrengen zonder lumen, BW zonder actieve Leydigcellen
- Prepuberteit (10-14 jaar): lumen verschijnt, ++ diameter, Leydigcellen actief
- > 14 jaar: spermatogenesis begint
Spermatogeen epitheel: (=zaadepitheel)
- Rust op basale membraan
- Laag platte, contractiële cellen = myoïde cellen
- Losmazig BW met cellen van Leydig en ++
capillairen
- Cellen van Leydig: (= interstitiële cellen)
Polygonale cellen met grote kern
++ GER en MT
++ kleine lipidedruppels
Fctie: productie testosteron
- Sertollicellen:
Hoge, onregelmatige cilindrische cellen
Basaal membraan lumen
++ GER
Zonulae occludentes: bloed-testisbarrière
, Apicaal: rijpe spermatozoa met flagellen
Fctie: voeden en onderhouden geslachtscellen + aanmaak androgeenbindend
proteïne en inhibin
- Zaadcellen:
Spermatogonium (A en B)
Spermatocyt I
Spermatocyt II
Spermatiden vroeg/laat
Spermatozoa
*testiskanker: kanker van de zaadcellen
Spermatogenesis:
Afhankelijk van:
- Hypothalamus: GnRH
- Hypofyse: LH en FSH
- Leydigcellen: testosteron
- Sertollicellen: ABP en inhibin
- Temperatuur: 35°C
Spermiogenesis: (=differentiatie spermatide spermatozoa)
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