Exam (elaborations)
MCB 2210 EXAM
- Course
- MCB 2210
- Institution
- University Of Connecticut
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CYTOSOL >-
NUCLEVS post translation CYTOSOL >
-
ER cotran
·
CYTOSOL >
-
NUCLEVS · ER FUNCTION
terminal signal sea , If charged 5-7 ad ↳ protein synthesis Secretory
"
C -
: &
not removed after translation completion ↳ lipid synthesis , cast & enzyme
- gated transport by agmous pore not directly across membrane
,
↳ CYTOSOL ER
post translational
o >
-
Mona
↳ N -
terminal Signal sea (signal p
·
SIGNAL SEQ : NLS (import] & NES /export ↳ cotranslational & SRP , SRP rece
↳ NLS , NES & Ran recycled ↳ SRP involved
Rasp transfer sea/
↳ protein who stop
·
IMPORT DSRD (signal recognition Partige)
D
mindo was
printin & JRP binds SRP receptor & ribo
nascent chain (new protein)
↳t
② SRP & SRP receptor release >
=
O N-terminal
sea cleared by s
-
translocon channel close ,
⑭
·
EXPORT A
after export
Ran GTP
& ↓
-
↑
p &
+ V+ + ribotome +
& => op
angp
]
GTP to
D &
portin
⑳ Sportin ↳ protein w/ stop/internal transf
-
not cleared of
trimetric
out transmemb
complex & TYPE I
↳ stop transfer sea made
Coor
stop
-term NH2
start
& TYPE 11
I
↳ internal starttransfer se
NU3
·
position of
ad
N/C -
terminal diff
③ TYPE III
200
-
A
I
an
NHst
·
, POST TRANSLATION = involve cytosolic chaperons
transmembrane transport
CUTOSOL >
-
MITOCHONDRIA , CHLOROPLAST & PEROXISOMES > GOLGI
ER-
·
MITOCONDRIA TARGETING · ER- GOLGI
↳ N -
terminal amphipathic signal , t marge ) ER-
↳
> Golgi & endocytosis
↳ post translational ↳ resicular transport , & fus
and
cytosolic chaperous :
help keep protein unfolded folded after transport ↳ constitutive secretion :
-
,
↳ mitochondrial matrix protein don't need signal > made in matrix retrograde :
ER-
Golgi > >
-
- -
↳ > 90 % Mitochondrial protein nuclear encoded & made in autoplasm -
resides budding off a cons
- regulatory secretion
anterograde Golgi : > ER
- -
protein made by nuclear genome -
stimulus driven
> need
- targeting sea to get into mitochondrial
·
VIRAL PROTEIN (USU-G)
a
↳ room
temp :
proper folding
- mitochondrial protein x need
> targeting sea ↳ @ & temp : not folded
&
prope
↳ ER-cis Golgi :
Sugar tree t
membrane
inner
membrane
wine
mitomonar
outer mitochondrial
(inner
NHst
↑ PROTEASE PROTECTION
S O
targeting sea cleared
energy from gradient
& protein protected during tra
① charge signal sea attract & inner membrane - microsome + protease >
-
no
- protein during/after synthe
·
CHOROPLAST TARGETING
↳ N -
terminal targeting signal ,
cleared
↳ post translational GOLG
o
↳ TOO & TIC ↳ ER-CGN-
>
cisGolgi > medial -
↳ to
get into thylakoid thylakoid targeting sea
: & stromal import seq CGN : delivery from ER
-
-
TGN : sorting & reside exit ,
cytosol
Y protein & golgi ER/
=> m
return to
T
importsea can
stroma
* tall id
targeting sea · COAT PROTEIN
thylakoid lumen
↳ help budding & select cargo t
↳ transmembrane
cargo receptors
·
PEROXISOMES CoP11 : ER- Golgi anterogr
↳ post translational
4 NIC -
term
,
targeting sea
fully folded
,
not removed
[ COP1
clathrin
:
Golgi
:
>
-
TGN/ surface
ER &
>
-
trans-Go
endoso
4 common translocon complex , unique receptor ↳ G-protein , lipid anchor
-
GTP bound ,
anchor expo
-
-
GDP bound , anchor hi
-
nonhydrolyzable GTP ->
no
sep translation X resume RAB
receptor => o
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