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Samenvatting H 28 Slaap Neuroscience $3.78   Add to cart

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Samenvatting H 28 Slaap Neuroscience

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Samenvatting van de lecture over het boek Neuroscience, Purves 6e editie, hoofdstuk 28. Voor de cursus Neurobiologie van Universiteit Utrecht. Inclusief verduidelijkende plaatjes

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  • Chapter 28
  • June 20, 2020
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  • 2019/2020
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By: rosaliedekuijer1 • 3 year ago

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Slaap Neurobiologie

Leerdoelen

Hoorcollege
Moleculaire mechanismen van de biologische klok
- 2 genen in de hypothalamus (SCN): Bmal1 en Clk
- Van deze genen wordt mRNA gemaakt
- mRNA gaat de kern uit en hier worden eiwitten van
gemaakt
- De eiwitten van Bmal1 en Clk vormen een dimeer en
gaan de nucleus in
- In de nulceus gaan deze op enhancers van genen zitten
wat resulteert in het tot expressie brengen van de genen
- De genen waar het aan bindt zijn Cry, Ccg en Per, hier
wordt weer mRNA van gemaakt en vervolgens weer eiwit
- Cry en Per eiwitten vormen een dimeer
- Deze inhibeert de Bmal1/Clk dimeer en zorgt dat de
Bmal1 en Clk expressie toeneemt




De suprachiasmtische nucleus (SCN) als biologische klok
- Suprachiasmatische nucleus bevindt zich in paraventricular nucleus in de
hypothalamus
- Krijgt input van retinale ganglioncellen

Functies van slaap
- Hersenen
o Learning & memory
o Metabole regulatie
 Aanvullen glycogeen levels in het brein
- Lichaam
o Imunne function
o Metabole regulatie
 Aanvullen glycogeen

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