Samenvatting ALGEMENE FARMACOLOGIE - VOLLEDIG FORMULARIUM MET UITLEG
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Course
Farmacologie
Institution
Universiteit Gent (UGent)
Een volledig, uitgebreid en gestructureerd overzicht van alle farmacologische formules gedoceerd binnen het vak farmacologie aan Universiteit Gent, door Prof. De Cock.
àD = dosis
à CL = klaring
./'%&'(#'$#$)*+')
𝐹,-% = ./',-
à Fabs = absolute biologische beschikbaarheid
à AUC = hetzelfde preparaat, andere toedieningsweg
./'.
𝐹0&1 = ./' à Frel = relatieve biologische beschikbaarheid
/'0
à AUC = dezelfde toedieningsweg, hetzelfde actieve
bestanddeel, nieuw referentiepreparaat
𝐹 = 𝑓, ∗ 𝑓" ∗ 𝑓2 à fa = geabsorbeerde fractie
à fi = fractie die intestinaal opgenomen en niet
gemetaboliseerd wordt
à fh = fractie die hepatisch niet wordt afgebroken
𝐶3456 = 𝑓$ ∗ 𝐶787 à fu = unbound fraction
.
𝑉! = ' à Vd = verdelingsvolume
1
àA = hoeveelheid drug in het lichaam
à Cp = plasmaconcentratie
*9%"%
𝑉! = '1,3
à Cp,0 = plasmaconcentratie (t=0 na IV)
𝐶𝐿 = 𝑓$ ∗ 𝐶𝐿":; à CLint = intrinsieke klaring
1
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