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Samenvatting ALGEMENE FARMACOLOGIE - VOLLEDIG FORMULARIUM MET UITLEG $3.26   Add to cart

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Samenvatting ALGEMENE FARMACOLOGIE - VOLLEDIG FORMULARIUM MET UITLEG

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Een volledig, uitgebreid en gestructureerd overzicht van alle farmacologische formules gedoceerd binnen het vak farmacologie aan Universiteit Gent, door Prof. De Cock.

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  • August 18, 2020
  • 3
  • 2019/2020
  • Summary
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Farmacologie – Formules
Farmacokinetiek
'! ('"
𝑣!"##$%"& = 𝐷 ∗ 𝑃 ∗ 𝑂 ∗ !
àD = Diffusiecoëfficiënt

àP = Vet-waterpartitiecoëfficiënt
àO = Oppervlak
àd = Diffusieafstand (membraandikte)
)
𝑝𝐻 = 𝑝𝐾𝑎 + log () # )
$#
)$#
𝑝𝐻 = 𝑝𝐾𝑎 + log ( ) ) à ci = concentratie geïoniseerd
#

à cni = concentratie niet-geïoniseerd
*
𝐴𝑈𝐶 = 𝐹 ∗ '+ àF = biologische beschikbaarheid

àD = dosis
à CL = klaring
./'%&'(#'$#$)*+')
𝐹,-% = ./',-
à Fabs = absolute biologische beschikbaarheid

à AUC = hetzelfde preparaat, andere toedieningsweg
./'.
𝐹0&1 = ./' à Frel = relatieve biologische beschikbaarheid
/'0

à AUC = dezelfde toedieningsweg, hetzelfde actieve
bestanddeel, nieuw referentiepreparaat
𝐹 = 𝑓, ∗ 𝑓" ∗ 𝑓2 à fa = geabsorbeerde fractie
à fi = fractie die intestinaal opgenomen en niet
gemetaboliseerd wordt
à fh = fractie die hepatisch niet wordt afgebroken
𝐶3456 = 𝑓$ ∗ 𝐶787 à fu = unbound fraction
.
𝑉! = ' à Vd = verdelingsvolume
1

àA = hoeveelheid drug in het lichaam
à Cp = plasmaconcentratie
*9%"%
𝑉! = '1,3
à Cp,0 = plasmaconcentratie (t=0 na IV)

𝐶𝐿 = 𝑓$ ∗ 𝐶𝐿":; à CLint = intrinsieke klaring




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