These substances stimulate nerve endings, starting the pain process.
Rubbing a painful area with massage or liniment stimulates large sensory fibers
Result
Closes gate
Reduces pain sensation
Adjuvant Drugs
Assist primary drugs in relieving pain
NSAIDs
Antidepressants
Anticonvulsants
Corticosteroids
Example: adjuvant drugs for neuropathic pain
Amitriptyline (antidepressant)
Gabapentin or pregabalin (anticonvulsants)
World health organization 3-Step Analgesic Ladder
Step 1: non-opioids (with or without adjuvant medications) after the pain has been
identified and assessed. If pain persists or increases, treatment moves to
Step 2: opioids with or without non-opioids and with or without adjuvants. If pain
persists or increases, management then rises to
Step 3: opioids indicated for moderate to severe pain, administered with or without non-
opioids or adjuvant medications. (this should be the very last)
2
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