100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Complete summary mechanisms of disease 1 $13.66   Add to cart

Summary

Complete summary mechanisms of disease 1

1 review
 69 views  5 purchases
  • Course
  • Institution
  • Book

Complete summary of the course mechanisms of disease I. Contains many images and clear explanations of all the material that was discussed during the lectures.

Preview 4 out of 150  pages

  • Unknown
  • October 3, 2020
  • 150
  • 2020/2021
  • Summary

1  review

review-writer-avatar

By: mooscastelijn • 3 year ago

reply-writer-avatar

By: lottefokker • 3 year ago

Translated by Google

Reply deleted by the user

avatar-seller
Lectures mechanisms of disease I

Theme 1 the immune system and its opponents
Lecture 1 introduction

It is most of the time not completely clear why a disease is formed.

Lecture 2 introduction to the immune system
Parham chapter 1,2,10

There are al lot of pathogens and all are different

3 layers of defence mechanisms
1. Physical, chemical and microbial barriers
2. Innate immune system, the signal is a bit larger than the first one
3. Adaptive immune system

Respiratory tract
Tight junctions between cells, some areas with space (mucus cells)
Cilia (little hairs) to wipe out the mucus out the longs to the mouth for example, prevents
bacteria kolonization

When there is something wrong
there is an immidiate response to
get rid of those bad cells by tissue
residence cells

,Cells
o Cells between are red blood cells
Don’t have a nucleus
o Lymfocyten
Small, not much cytoplasma
o Monocytes
More cytoplasm, bit bigger
o Neutrophil
Little vesicles with lithic enzymes
o Eosinophil
Vesicles
o Basophil
For allergic responses




Innate immunity (primitive form of immune system)
Immune cells start with the hematopoetic stem cells
All kind of other types like macrophage, NK cells, dendritic cells and mast cells.

o Rapid response (hours)
o Fixed
o Limited number of specificities
o Constant during response

Adaptive immunity
Adaptive immune system
B- and T- lymfocytes

o Slow response (days to weeks)
o Variable
o Numerous highly selective specifies
o Improve during response

→ They both come together for the destruction of pathogens.

,Lack of these immunity the infection can take very long
• Innate immune system
You die because the adaptive immune system is not
working very fast.
• Adaptive immune system
Initially a little bit control but when the adaptive system
needs to take over, you will also die.

Location of the immune cells
There are a lot of immune cells in the blood.
Primary/secondary lymfoid organs contain a lot of T- and B-
cells. All those lymfe nodes are connected with each other.
Ductus thoracicus collects all the lymfe, after this it will go into the circulation.
Primary: thymus, bone marrow
Secondary: spleen, gut associated lymfathic tissue, adenoid, tonsil


B-cells are produced in the bone marrow
and they are mature.

T-cells are at first precursors in the bone
marrow and they develop in the thymus.
Mature T-cells leave the thymus and
travel to the secondary lymfoid tissues.

, Most of the secondary lymfoid tissue is localized in the gastro-intestinal tract
• GALT (gut associated lymfoid tissue)
Tonsils, adenoids, appendix, mesenteric lymfnodes. Peyer’s patches
• BALT (bronchus associated lymfoid tissue)
All lymfnodes draining respiratory epithelium
• MALT (mucosa-associated lymfoid tissue)
Remaining more diffusely organized lymfoid structures at all mucosal surfaces

Lymf node route
o Afferent vessel
o Marginal sinus
o It goes to the centre
o In the medulla the lymf is collected
o Efferent vessel
o Next lymf node or ductus thoracicus

There is also an incoming artery, outgoing vein for oxygen

T- and B-cells live in different areas
- Yellow: B-cells
- Blue: T-cells
- Red: plasma cells produce
antibodies

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller lottefokker. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $13.66. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

81113 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$13.66  5x  sold
  • (1)
  Add to cart