Summary
Concise summary of the Musculoskeletal system
- Course
- Institution
- Book
Summary of the Musculoskeletal system
[Show more]
Connected book
Book Title:
Author(s):
- Edition:
- ISBN:
- Edition:
More summaries for
-
Summary of the Nervous System DRUGS
-
Concise summary of the Emergency Tx of Poisoning
-
Concise summary of Anaesthesia
1 review
By: rubana8 • 2 year ago
Seller
Follow
anmoll
Reviews received
Content preview
Chapter 10 – MSK SystemSPONDYLOARTHRITIS
Chapter 10 –
Affects both axial and peripheral joints
Musculoskeletal
System Tx for axial spondylarthritis
NSAID – at lowest effective dose
TNF-alpha inhibitor
OSTEOARTHRITIS
For severe non-radiographic axial
Treatment spondylarthritis = adalimumab,
Paracetamol +/- NSAID – regularly certolizumab, etanercept
Topical NSAID or capsaicin 0.025% - esp. in
Psoriatic arthritis = local corticosteroid
hand and knee OA
injections, standard DMARDs, NSAID
Sodium hyaluronate – post ankle sprain
Reactive arthritis = after treating initial
RHEUMATOID ARTHRITIS infection, avoid long-term Tx (>4 weeks) with an
Persistent symmetrical joint synovitis AB solely to manage RA caused by a GI
typically of the small joints of hands/feet intestinal or genito-urinary infection
Synovitis = pain and prolonged stiffness Rheumatic disease – suppressing drugs
that’s worse at rest or inactivity, swelling, 1. Gold (sodium aurothiomalate) – given via
tenderness and heat, rheumatoid nodules, deep IM and area gently massaged.
malaise, fatigue, fever, weight loss Weekly doses given incl. test dose
Palindromic rheumatism – causes attacks of 2. Penicillinamine – discontinue if there’s no
joint pain and swelling improvement in 1 year
Drug Tx 3. Sulfasalazine – haematological effects may
occur in the first 3-6 months of Tx and are
1st line in newly diagnosed = DMARD reversible on cessation
(sulfasalazide, MTX or leflunomide) or 4. Antimalarials (hydroxychloroquine,
hydroxychloroquine chloroquine) – effective for mild SLE but
Bridging Tx as DMARDs have a slow onset avoid in psoriatic arthritis
of action (2-3 months) = corticosteroid
(oral, IM or intra-articular) Drugs affecting the immune response
Add-on Tx = a 2nd DMARD or hydroxy. 1. MTX – given once weekly.
Poor response to combination Tx = tumour 2. Leflunomide – therapeutic effect starts after
necrosis factor (TNF) alpha inhibitor 4-6 weeks
Severe, active RA = rituximab Juvenile idiopathic arthritis = MTX or
Pain relief = oral NSAID, paracetamol or sulfasalazine
selective COX-2 inhibitor. Use PPI to reduce
GI effects. Withdraw NSAID if not needed
If maintained Tx for at least 1 year without
corticosteroids, reduce drug dose to lowest
clinically effective dose or taper and stop at
least 1 drug if being treated with >1 DMARD
Surgery – if Tx has failed, there’s worsening of HYPERURICAEMIA AND GOUT
joint function, progressive deformity or
persistent localised synovitis Acute attacks of gout = NSAID (diclofenac,
etoricoxib, indomethacin, ketoprofen, naproxen,
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller anmoll. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.81. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
62890 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now