Samenvatting van alle Research stof van semester 3 (Q5 en Q6).
Deze samenvatting bevat de modules: population, modelling systemic therapy, wet lab research, meta-analysis and more en measuring and modelling reflexes.
Geschikt voor tweedejaars biomedische wetenschappen studenten van de Radboud Un...
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Q5..........................................................................................................................................................2
Modelling systematic therapy...........................................................................................................2
Population.........................................................................................................................................4
Wet lab..............................................................................................................................................6
Systeemtherapie............................................................................................................................6
Hypoxie in radiotherapie en radiologie..........................................................................................7
Pathways en western blotting........................................................................................................8
Q6........................................................................................................................................................12
Measuring and modelling reflexes...................................................................................................12
Part I: Force and the moment of force.........................................................................................12
Part II: Measuring and modelling reflexes...................................................................................13
Meta-analysis and more..................................................................................................................19
1
, Samenvatting research semester 3
Q5
Modelling systematic therapy
d
V c ( t )=D ( t )−k c (t )
t
o Systeem vergelijking
d
o Evenwicht? c ( t )=0 c ( t ) =D(t)/k
dt
Lineair systeem
o Als een 2x zo grote input resulteert in een 2x zo grote output
Non-lineair systeem
o Moeilijk om zelf een oplossing te vinden niet voor Simulink
o Gedragen zich niet ‘smoothly’
Onderzoeksvraag vertalen naar Simulink
o 1. Systeem vergelijking vinden
change out
= ¿ −
time time time
d
V c ( t )=D ( t ) −k c (t)
dt
o 2. Differentiële vergelijking omzetten naar integraal
1
c ( t ) =∫ ( D ( t )−k c ( t ) )
V
o 3. Model bouwen rondom integraal
In lineair kinetics is de eliminatie proportioneel aan de concentratie in het compartiment
o Ψ ( t )=k ∙ c (t)
d
Steady state als c ( t )=0
dt
Rechter compartiment hierboven
d
o V1c ( t ) =D ( t )−k 12 c 1 (t ) +k 12 c 2 ( t )−k 10 c 1 (t )
dt 1
d
o V 2 c 2 ( t ) =k 12 c1 ( t )−k 21 c 2 ( t )
dt
2
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