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Summary Research Q8 Biomedical Evidence - Biomedical Sciences Radboud University $12.36
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Summary Research Q8 Biomedical Evidence - Biomedical Sciences Radboud University

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  • Course
  • Research
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  • Radboud Universiteit Nijmegen (RU)

Summary of all research Q8 substance. This summary contains the following modules: bioinformatics and big data, personalized healthcare, infectious diseases and global health, Alzheimers' disease and stress related disorders and nanomedicine. Suitable for second-year biomedical sciences stud...

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  • November 16, 2020
  • 28
  • 2019/2020
  • Summary

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  • Radboud Universiteit Nijmegen (RU)
  • Biomedische Wetenschappen
  • Research
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Samenvatting Research Q8



Personalized healthcare research
• Economische evaluatie
o Vergelijkende analyse van 2 of meer alternatieven in termen van kosten en
opbrengsten
o Soorten:
▪ Kosteneffectiviteitsanalyse → eenheden van klinisch effect (bijvoorbeeld
kosten per bloeddrukverlaging)
▪ Kostenutiliteitsanalyse → voor kwaliteit gecorrigeerde levensjaren
▪ Kostenbatenanalyse → monetair
o Incrementele kosteneffectiviteitsratio (IKER)
▪ Kosten nieuw – kosten controle / effect nieuw – effect controle
▪ Interventie is kosteneffectief als IKER onder de drempelwaarde ligt
▪ Maximum van 80.000 euro per QALY voor ziekte met hoge ziektelast
• Headroomanalyse
o Maximale potentiele waarde van de innovatie
o Vergelijking perfecte strategie → maximale delta E
o Vaak uitgedrukt in quality-adjusted life years
o Maximale delta E x drempelwaarde – eventuele kosten delta C = maximale waarde
van innovatie

Big data and bio informatics
Algemeen

• Thesaurus / vocabulary → collection of terms, definition and synonyms
• Ontology → describes the relationships between terms in the thesaurus and to external
databases
o For example:
▪ DMD has phenotype muscle fibrosis
▪ DMD → subject
▪ Has phenotype → predicate
▪ Muscle fibrosis → object
• FAIR principles
o Findable → easy to find by both humans and computer systems and based on
mandatory description of the metadata that allow the discovery of interesting
datasets
o Accessible → stored for long term such that they can be easily accessed and/or
downloaded with well-defined license and access conditions, whether at the level of
metadata or at the level of the actual data content
o Interoperable → ready to be combined with other datasets by humans as well as
computer systems
o Reusable → ready to be used for future research and to be processed further using
computational methods




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