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Samenvatting ZEZI: Fysiologie van neurotransmitters en hun receptoren (krap budget? Stuur me een bericht voor een lagere prijs!) $8.64
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  3. Universiteit Gent (UGent)
  4.  
  5. Geneeskunde
  6.  
  7. ZEZI (DX00038)

Summary

Samenvatting ZEZI: Fysiologie van neurotransmitters en hun receptoren (krap budget? Stuur me een bericht voor een lagere prijs!)
 3 purchases
  • Course
  • ZEZI (DX00038)
  • Institution
  • Universiteit Gent (UGent)

H3.1 van het partim fysiologie, uit het blok zenuwstelsel en zintuigen, staat hier samengevat. Het betreft alle neurotransmitters en hun receptoren.

Last document update: 4 year ago

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Document information

  • December 29, 2020
  • January 1, 2021
  • 6
  • 2020/2021
  • Summary

Subjects

  • zezi
  • zenuwtselsel
  • zintuigen
  • fysiologie
  • neurofysiologie
  • leybaert
  • neurotransmitters
  • receptoren
  • ach
  • noradrenaline
  • dopamine
  • serotonine
  • histamine
  • aspartaat
  • glutamaat
  • gaba
  • glycine
  • atp
  • adeno
  • hoofdstuk 31
  • h3

Written for

  • Universiteit Gent (UGent)
  • Geneeskunde
  • ZEZI (DX00038)
All documents for this subject (14)

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Content preview

Acetylcholine
 AcCoA + Choline  Ach (acetylcholinesterase)
 Ionotroop:
o 2 Ach, pentameer
 Metabotroop:
o M1,3,5 stimuleren PLC, Ca2+ stroom ↑
o M2,4 inhiberen AC, K+ stroom ↑
 Lokale hypocalcemie:
o Presyn: neurotransmitter loslating ↓
o Postsyn: exciteerbaarheid ↑ (unshielding neg ladingen buiten)
 Baan:
o Cholinerge nucl thv dorsale tegmentum
o Nucl basalis Meynert (<RAS)  neocortex, hippocampus, amygdala
 Arousal, Aandacht, Perceptie, Geheugen, Cognitie, REM (dromen)
 Thalamus gating via TRN

(Mono)amine-neurotransmitters
Noradrenaline
 Tyrosine  Dopa  Dopamine  noradrenaline (dopamine β hydroxylase)
 Afbraak MAO + COMT
 Dorsale bundel:
o Locus ceruleus (<RAS)  ruggenmerg, cerebellum, supraoptische+paraventr nuclei
hypothalamus, neocortex
o Alertheid/waakzaamheid onverwachte stimuli:
β1 receptoren -> Ca2+ ↓ -> K(Ca) kanalen ↓ -> exciteerbaarheid ↑ -> alertheid ↑
 Ventrale bundel/lateraal tegmentaal:
o DMNV+NTS  ruggenmerg, cerebellum, hypoth, basale telencefalon
o Regulatie hypofysaire hormonen
 α2 receptor = autoreceptor (inhibeert verdere loslating noradr)
 gemoed+stemming: daling noradr  psych depressie

Dopamine
 D1 familie (D1,D5) : cAMP↑, Ca2+ signalisatie (PLC)↑
 D2 familie (D2,3,4) : cAMP↓, Ca2+ signalisatie (ψ) ↓, K+ stroom↑
 D2 receptor = autoreceptor (amfetamine, cocaïne)
 Banen:
o Mesolimbisch (+Schizofrenie)
o Mesocorticaal (-Schizofrenie)
o VTA-NA baan (beloning, nicotine, alcohol, opiaten, cannabinoïden)
o Tubero-infundibulair
o Nigrostriataal (Parkinson)
 ADHD (dop↓), novelty-seeking

, Serotonine 5-HT
 Tryptofaan  5HT (na hydrox + decarbox)
 Afbraak MAO + 5HIAA tot metaboliet urine of tot melatonine
 Baan:
o Nucl raphe (<RAS)  hypoth, limb syst, neocortex, cerebellum, ruggenmerg
 Ionotroop:
o 5HT3 exc braakreflex, anti-emeticum
 Metabotroop:
o 5HT1 inh angst, depressive (anxiolyt) / impulsiviteit agressie / migraine
o 5HT2 exc hallucinaties psychose (atyp antipsychotica) / voeding en geheugen (obesitas)
o 5HT4 exc
o 5HT5 inh
o 5HT6 exc limb system: gemoed+stemming
o 5HT7 exc limb system: gemoed+stemming
1A,4,6 ook geheugen+leerprocessen
5HT transporter depressie, autisme, ADHD, eetstoornissen
MAO-A alcoholisme, agressie, angst, antisociaal gedrag
 Synaptic cradle (tripartite+microgliacellen)
 Depressie: (Inbalans neuronale celdood en neurogenese)
o Tekort serotonine
o Glutamaat
o BDNF (groeifactoren)
o Stress: Glu, Noradr, cortisol
 SSRI (fluoxetine) inhibeert presyn re-uptake
 Hallucinogene subs: LSD, psilocine, mescaline, ecstasy = MDMA
 Beëindigen REM slaap

Histamine
 Histidine  histamine (decarb)
 Afbraak MAO + diamine oxidase
 Baan:
o Nucl tuberomammillaris (<RAS)  bijna alle delen
 Metabotroop:
o H1 PLC activatie (H1R antagonisten voor hooikoorts, bijwerking slaperigheid)
o H2 AC activatie
o H3 autoreceptor

Aminozuurneurotransmitters
Aspartaat
 Oxaloacetaat  asp (transaminatie)
 Excitatorisch (rol in visuele cortex)

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