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Samenvatting: Parkinson
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NeurologieDocent: Rishi Panday
Parkinson
Parkinson: meer dan beven?!
● Inleiding: voorkomen van ziekte van Parkinson
= Primair neurodegeneratieve aandoening (= geen duidelijke oorzaak + Aftakeling
van hersenweefsel)
● Motorische verschijnselen
- Rusttremor
(= beven in rust)
- Bradykinesie
(=traag bewegen)
- (Tandrad)rigiditeit
(= stijfheid, beweging
die shokkend verloopt)
● Niet-motore verschijnselen
- Sensorisch
- Autonome dysfunctie
- Slaapstoornissen
- Neuropsychiatrisch
● Pathologie: Selectieve degeneratie van de dopaminerge neuronen in de
substantia nigra (foto → Afsterven van zenuwcellen) )
- Lewy-bodies: insluitsels van alfa-synucleine
= Idiopatische ziekte van Parkinson
VS secundair parkinsonisme (de klachten lijken op parkinson maar ze worden veroorzaakt
door andere aandoeningen)
Secundair parkinsonisme kan veroorzaakt worden door bepaalde medicatie:
- Neuroleptica
- Cinnarizine
- Flunarizine
- Vasculair
Prevalentie:
- 0,3 % in de algemene populatie
- 1,6 % in 65+
- 10 % in 80+
- Begin tussen 50 en 70k
KLINISCHE DIAGNOSE
→ Motorische verschijnselen:
- Rusttremor
- Bradykinesie
- (tandrad)rigiditeit
1
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