Summary
Sumario NOCARDIA MICROBIOLOGIA
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Todo acera de Nocardia, como tratar las manifestaciones clinicas, como se manifiesta, su virulencia, fisi0logia, etc.
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NOCARDIA● Bacilos gram positivos, aerobios estrictos.
● Forman filamentos ramificados en los tejidos y los cultivos.
● Los filamentos se parecen a las hifas generadas por los hongos
● Antes se pensaba que Nocardia era un hongo; sin embargo, los microorganismos
tienen una pared celular gram positiva y otras estructuras celulares propias de las
bacterias.
● Se describe como á cido-alcohol resistente débil.
Fisiologia
Catalasa-Positivas, Oxidan carbohidratos , Capaces de crecer en la mayoría de los
medios de laboratorio no selectivos para bacterias, micobacterias y hongos; su
aislamiento puede requerir entre 3 y 5 días de incubación antes de poder reconocer
colonias en placas de cultivo
Virulencia
● Asocia a la capacidad de evitar la destrucción intracelular
● Catalasa y superóxido dismutasa:
Inactivan metabolitos tóxicos del oxígeno (como peróxido de hidrógeno y superóxido)
● Cord factor:
Impide la eliminación intracelular de la bacteria en los fagocitos al interferir en la fusión
de los fagosomas con lisosomas.
Epidemiologia
Universal , En suelos enriquecidos con m ateria orgánica , Las infecciones exógenas se adquieren
por: Inhalación (pulmonar) , I noculación traumática (cutánea) ,Patógeno oportunista, Pacientes
inmunodeprimidos , Deficiencias de linfocitos T (receptores de trasplante, pacientes con
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