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Sumario EICOSANOIDES Y LA HISTAMINA EN FARMACOLOGIA
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Todo acerca de los eicosaniodes, farmacos, histamina en la farmacologia, vias como la COX
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EICOSANOIDES¿Qué son? Sustancias con diversas acciones fisiológicas y sintetizadas a partir de ácidos
grasos poli-insaturados, se originan a través de la membrana celular (plasmática).
ACIDO ARAQUIDONICO
-Es un derivado del ÁCIDO LINOLEICO.
-Se ingiere de las dietas (carnes).
-Se almacena formando parte de los fosfolípidos de la membrana celular.
LIBERACIÓN DEL ÁCIDO ARAQUIDÓNICO
-Generada por Impulsos nerviosos, antígenos, reacciones inmunitarias, isquemia, daño celular,
neuropéptidos y hormonas.
-VÍA DE LA CICLO- OXIGENASA
COX-1 y COX-2, y COX-3
COX1: Aumento de la adhesión plaquetaria, aumento del flujo renal, aumento de la mucosa
gástrica. A partir de aquí se originan las prostaglandinas y los tromboxanos.
COX-2: Inflamación, rubor, calor y dolor.
COX-3: Encontrada en el hipotálamo, por lo que esta causa fiebre, el Paracetamol es un
farmáco que actúa sobre la COX-3 por lo cual tiene efecto antipiretico
-VÍA DE LA LIPOOXIGENASA Se derivan los leucotrienos.
ISOENZIMAS COX
CICLO- OXIGENASA-1(COX)
-Enzima constitutiva.
-Encargada de sintetizar PG’s implicadas en la HOMEOSTASIS.
CICLO- OXIGENASA-2 (COX-2)
-Indetectable basalmente en la mayoría de los tejidos.
-Produce PROSTANOIDES en los lugares inflamados.
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