Samenvatting en ZSO Immunologie (3de bachelor Biologie)
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Course
Immunologie
Institution
Universiteit Hasselt (UHasselt)
Book
Basic Immunology
Dit is de samenvatting van het volledige vak Immunologie gegeven door professor Hellings aan de UHasselt. Naast de samenvatting bevat dit ook ZSO 1 tot en met 9 die doorheen het semester vallen.
Geïnfecteerde cellen produceren type I IFN (door TLR signaling) IFN op receptoren van (niet-)geïnfecteerde
cellen signalisatiepathway enzymen interfereren met virale replicatie, inhiberen genexpressie, induceren
expressie van genen voor meer CTLs (deze laatste: als IFN bindt op geïnfecteerde cel)
Activatie DC door microben expressie chemokine receptoren (CCR7): homing naar T-celzones in lymfeknopen
(of milt)
APCs:
Dendritische cellen: meest potente APCs, activatie naïve T lymfocyten
Macrofagen: in alle weefsels, fagocytose van microben display AG aan effector T cellen activatie macrofagen
B lymfocyten: nemen proteïne AG op display aan helper T cellen in lymfeweefsels
Structuur MHC (major histocompatibility complex):
Eigenschappen MHC:
Polymorfe genen: verschillende individuen reageren op verschillende peptiden.
Co-dominante expressie: expressie van beide parentale allelen meer verschillende MHCs.
Klasse I: expressie op alle cellen met nucleus.
Klasse II: expressie op DC, macrofagen en B lymfocyten (APCs).
Binding van peptiden:
Brede specificiteit: veel verschillende peptiden op 1 MHC
1 peptide per keer
MHC: enkel binding van peptiden (geen lipiden, suikers)
Op het celoppervlak: enkel MHCs geladen met peptiden
Trage off-rate: genoeg tijd voor herkenning
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