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College Erytrocyten
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College over erytrocyten. Gegeven door Henny Renting.
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Hoorcollege erytrocytenBiconcaaf schijfje, in vorm gehouden door spectrine
Begrippen:
• Basiskennis over rode bloedcellen
• Vormafwijkingen van rode bloedcellen, bruikbaarheid in de diagnostiek
• Anemie: indelen aan de hand van gemiddelde celvolume
• Anemie: Bloedarmoede
Hematocriet
• Voorbeeld: = 45/100 = 0.45
o Is het volume van het bloed dat door rode bloedcellen wordt ingenomen,
weergegeven als een fractie van het totale bloedvolume
Samenstelling en functies van bloed:
• O2 er in
• CO2 er uit
• Transport
• Afweer
• Temperatuur
,Bloedkweken bij verdenking sepsis
NaCitraat bindt Ca. Meestal voor de bloedstolling
LiHeparine remt de vorming van trombine. Voor chemie bepalingen
K2EDTA bindt Ca. voor de bloedcellen en enkele vitamines
NAF remt glucoseverbruik door de rode bloedcel
Bezinking van erytrocyten:
, •
• Verschuiving concentraties IgG, IgA, IgM. Sterke verdenking op Multiple Myeloom (ziekte van
Kahler)
Geldrolvorming:
•
Principes van celtelling:
• 1956: telkamer m.b.v. microscoop
• 1981: impedantie m.b.v. spanningsverschillen
o Impedantie: Coulter is hiermee begonnen
• 2019: Optisch m.b.v. flowcytometer in de automaat
o Impedantie in dezelfde automaat
• 2020: Nieuwe automaat Sysmex, Cell Vision
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