ACTION:
Same
mechanism
of
action
as
penicillin,
but
tend
to
be
more
resistant
to
beta-‐
lactamases.
They
are
divided
into
generations
based
on
their
bacterial
susceptibility
and
resistance
to
beta-‐
lactamases.
May
be
susceptible
to
ESBL
(extended-‐spectrum
beta-‐lactamases).
Generally
poor
oral
absorption.
IV
and
IM
preferable.
All
cross
placenta.
Highest
rate
of
cross-‐sensitivity
between
penicillin
Management
in
sepsis
and
meningitis.
But
inferior
to
treatment
against
MSSA
compared
to
1st
generation
cephalosporins.
Enhanced
activity
3rd
and
4th
against
HENPEcK
+
Pseudomonas
aeroginosa.
generation
has
to
Not
effective
against
LAME
=
Listeria
(Ampicillin),
Atyipcals/mycoplasma
some
extent
(macrolides),
MRSA
(Vancomycin),
Enterococci
(Amoxicillin
or
replaced
the
Ampicillin).
aminoglycosides
• Ceftriaxone
• Cefotaxime
• Ceftazidime
(Fortum)
• Cefoperazone
4th
generation
Kills
E.
coli,
Klebsiella
pneumoniae,
Proteus
mirabilis,
Pseudomonas
• Cefepime
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