Class notes
Biochemistry Enzyme Inhibition Lecture Notes
- Course
- Institution
These notes contain the material covered during the lecture, they are not a complete summary of the textbook chapter.
[Show more]
Seller
Follow
lmvw
Content preview
Enzyme InhibitionInhibitors
substance that reduces activity of enzymeby binding to it in
some way
combines with enzyme in way that influences binding of
substrate Ellor turnover number
Inhibitors ND understanding functionality of enzyme
Affect V Max hence affect enzyme activity
May resemble substrate structurally
can compete with sub for active rite
ManyDrugs inhibitors that block action ofspecific enzyme
Reversible vs irreversible
weakbindinginteractions inhibitor remainsboundto enzyme
non covalentinteractions strong covalentinteractions
Hbonds bind to residues AAsidechains
Hydrophobic a prosthetic
groups otherthanA
v d Waals eg Hernegrouponhaemoglobin
y activeenzyme9
Types to
Classicalcompetitive bindsn'te
panautre
St I bind to active rite mutually exclusive e
I resembles S
structural similarity between 7 a 8 binding site 1
I competes with for active rite
8
S bound enzyme I cannot bind
to
KI
E tS f ES Et P
WT E
WT t
KI
11 I
PI H
WT ki
EI
b Freeenzyme
Effectively b SJ available to enzyme 9km
because appears as if 8 binding lesstightly lb bindingaffinity
If ST SSS IT then I becomes negligible Vmax constant
unchanged
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller lmvw. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $2.92. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
85169 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now