uitgebreide samenvatting voor het vak Bloed en Bloedvormende organen (DGK jaar 1). Bevat een samenvatting van ziekteleer, aantekeningen en uitwerkingen van practica en enkele werkcolleges en veel handige plaatjes. 51 pagina's
Samenvatting BB
Inhoud
Ziekteleer................................................................................................................................................6
Anemie...............................................................................................................................................6
Pathofysiologie van anemie................................................................................................................6
Verschijnselen.................................................................................................................................6
Bloedverlies....................................................................................................................................6
Hemolyse........................................................................................................................................7
Gestoorde erytropoëse...................................................................................................................8
Secundaire non-generatieve anemie..............................................................................................8
Aanpak van anemie in de praktijk.......................................................................................................8
Anamnese.......................................................................................................................................8
Lichamelijk onderzoek....................................................................................................................8
Diagnostiek.....................................................................................................................................9
Differentiële diagnose....................................................................................................................9
Therapie..........................................................................................................................................9
Aandoeningen die gepaard gaan met bloedverlies............................................................................9
Rund...............................................................................................................................................9
Kleine herkauwers..........................................................................................................................9
Varken..........................................................................................................................................10
Paard............................................................................................................................................10
Hond.............................................................................................................................................10
Aandoeningen die gepaard gaan met hemolyse..............................................................................10
Hemotrope mycoplasma-infecties................................................................................................10
Babesiose (hond)..........................................................................................................................10
Piroplasmose................................................................................................................................10
Infectieuze anemie.......................................................................................................................10
Isoerytrolysis neonatalis...............................................................................................................11
Idiopathische immuungemedieerde hemolyse............................................................................11
Intoxicatie.....................................................................................................................................11
Koperstapeling..............................................................................................................................11
Aandoeningen als gevolg van een gestoorde erytropoëse...............................................................11
IJzergebrekanemieën....................................................................................................................11
Infectieuze anemie bij pluimvee...................................................................................................11
1
, Leishmaniose bij de hond.............................................................................................................12
Hemorragische diathese.......................................................................................................................12
Fysiologie van de hemostase............................................................................................................12
Het stollingsmechanisme..............................................................................................................13
De pathofysiologie van de hemostase..............................................................................................14
Storingen in de primaire hemostase.............................................................................................14
Storingen in de secundaire hemostase.........................................................................................15
Storingen in de primaire en secundaire hemostase.....................................................................15
De klinische gevolgen van hemorragische diathese.........................................................................15
Leukocytenafwijkingen.........................................................................................................................17
Fysiologie..........................................................................................................................................17
De granulo(cyto)poëse.................................................................................................................17
De monocytopoëse.......................................................................................................................17
De lymfopoëse..............................................................................................................................18
Invloed van stress en glucocorticoïden.........................................................................................18
Aandoeningen van de lymfoïde organen..............................................................................................18
Lymfeknopen....................................................................................................................................18
Bouw en functie van de gezonde lymfeknoop..............................................................................18
Reactiepatroon van lymfeknopen.................................................................................................18
Aanvullende diagnostiek bij lymfadenopathie..............................................................................19
Differentiële diagnose van lymfadenopathie................................................................................20
Infectieziekten die gepaard gaan met een lymfadenitis...............................................................20
Milt...................................................................................................................................................22
Miltvergroting – splenomegalie....................................................................................................23
Miltruptuur...................................................................................................................................24
Ontwikkelingsstoornissen van de milt..........................................................................................24
Neoplasieën van de milt...............................................................................................................24
Bursa Fabricius..................................................................................................................................24
Thymus.............................................................................................................................................25
Reactiepatroon van de thymus.....................................................................................................25
Neoplasieën van de thymus..........................................................................................................25
Beenmerg.........................................................................................................................................25
Neoplasieën van de lymfoïde organen.............................................................................................25
Leukemieën..................................................................................................................................25
Maligne lymfoom (lymfosarcoom)...............................................................................................26
Histiocytaire aandoeningen bij hond en kat.................................................................................26
2
, Plasmaceltumoren bij hond en kat...............................................................................................26
Tumoren van het hemopoëtisch systeem.....................................................................................27
Neoplasieën lymfoïdesysteem kip................................................................................................27
WC 1 voorbereiding..............................................................................................................................29
Functies van bloed............................................................................................................................29
Samenstelling van bloed...................................................................................................................29
Transport en opslag van zuurstof.....................................................................................................29
Stofwisseling erytrocyt.....................................................................................................................30
WC 2.....................................................................................................................................................31
EPO...................................................................................................................................................31
IJzerhuishouding...............................................................................................................................31
Tellen van bloedcellen......................................................................................................................31
Opdrachten.......................................................................................................................................32
WC 3.....................................................................................................................................................32
Zelfstudie-opdrachten......................................................................................................................32
PR1.......................................................................................................................................................32
PR 4 voorbereiding...............................................................................................................................33
Hematocrietbepaling........................................................................................................................33
Reticulocytentelling..........................................................................................................................33
Bloeduitstrijkje.................................................................................................................................33
Beoordeling rode bloedbeeld...........................................................................................................34
HC 6a....................................................................................................................................................35
Leukocytose......................................................................................................................................35
Immuunpathogenese...........................................................................................................................35
Transplantaten.................................................................................................................................35
Afstoting...........................................................................................................................................35
Voorkomen van afstoting.................................................................................................................36
Tumorimmunologie..........................................................................................................................36
Overgevoeligheidsreacties................................................................................................................36
Auto-immuniteit...............................................................................................................................36
PR 2 en 3...............................................................................................................................................37
Immuunelektroforese.......................................................................................................................37
Coombs test......................................................................................................................................37
Dubbele immunodiffusie..................................................................................................................37
ELISA.................................................................................................................................................38
PR 5......................................................................................................................................................38
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