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NSG530 / NSG 530 Exam 1 (Latest 2024 / 2025): Advanced Pathophysiology | Questions and Verified Answers | 100% Correct | Grade A - Wilkes CA$12.95   Add to cart
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NSG530 / NSG 530 Exam 1 (Latest 2024 / 2025): Advanced Pathophysiology | Questions and Verified Answers | 100% Correct | Grade A - Wilkes

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  • NSG 530 (NSG530)
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Exam 1: NSG530 / NSG 530 (Latest 2024 / 2025) - Advanced Pathophysiology Exam | Questions and Verified Answers | 100% Correct | Grade A - Wilkes Q: When antibodies are formed against red blood cell antigens of the Rh system, how are the blood cells destroyed? a. Complement-mediated cell lysis b. Ph...

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  • February 29, 2024
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  • 2023/2024
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  • advanced pathophysiology
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NSG 530 - Advanced Pathophysiology Exam 1 Question: When antibodies are formed against red blood cell antigens of the Rh system, how are the blood cells destroyed? a. Complement -mediated cell lysis b. Phagocytosis by macrophages c. Phagocytosis in the spl een d. Neutrophil granules and toxic oxygen products ANSWER : C Antibodies against platelet -specific antigens or against red blood cell antigens of the Rh system coat those cells at low density, resulting in their preferential removal by phagocytosis in the sp leen, rather than by complement -mediated lysis. These blood cells are not destroyed by complement -mediated cell lysis, phagocytosis by macrophages, neutrophil granules, or toxic oxygen products. Question: When soluble antigens from infectious agents e nter circulation, what is tissue damage a result of? a. Complement -mediated cell lysis b. Phagocytosis by macrophages c. Phagocytosis in the spleen d. Neutrophil granules and toxic oxygen products ANSWER : D Of the options available, only the components of neutrophil granules as well as the several toxic oxygen products produced by these cells, damage the tissue. Question: How are target cells destroyed in a type II hypersensitivity reaction? a. Compleme nt-mediated cell lysis b. Phagocytosis by macrophages c. Neutrophil granules and toxic oxygen products d. Natural killer cells ANSWER : D The mechanism that results in a type II hypersensitivity reaction involves a subpopulation of cytotoxic cells that are no t antigen specific (natural killer [NK] cells). Antibody on the target cell is recognized by Fc receptors on the NK cells, which releases toxic substances that destroy the target cell. The other options do not cause the destruction of target cells related to a type II hypersensitivity reaction. Question: Graves’ disease (hyperthyroidism) is an example of which type II hypersensitivity reaction? a. Modulation b. Antibody -dependent cell -mediated cytotoxicity c. Neutrophil -mediated damage d. Complement -mediated lysis ANSWER : A The antibody reacts with the receptors on the target cell surface and modulates the function of the receptor by preventing interactions with their normal ligands, replacing the ligand and inappropriately stimulating the receptor or dest roying the receptor. For example, in the hyperthyroidism (excessive thyroid activity) of Graves disease, autoantibody binds to and activates receptors for thyroid -stimulating hormone (TSH) (a pituitary hormone that controls the production of the hormone th yroxine by the thyroid). Graves disease is not a result of cell -mediated cytotoxicity, neutrophil -mediated damage, or complement -mediated lysis. Question: Type III hypersensitivity reactions are a result of which of these? a. Antibodies coating mast cells by binding to receptors that signal its degranulation, followed by the discharge of preformed mediators b. Antibodies binding to soluble antigens that were re leased into body fluids and the immune complexes being deposited in the tissues c. Tc cells or lymphokine -producing Th1 cells di rectly attacking and destroying cellular targets d. Antibodies binding to the antigen on the cell surface ANSWER : B Antigen -antibody (immune) complexes that are formed in the circulation and then deposited later in vessel walls or extravascular tissues cause most type III hypersensitivity diseases. Type III hypersensitivity reactions are not the result of antibodies coating mast cells to signal their degranulation, immune cells directly attacking and destroying t argets, or antibodies binding to the antigen on the cell surface. Question: A type IV hypersensitivity reaction causes which result? a. Antibodies coating mast cells by binding to receptors that signal its degranulation, followed by the discharge of preformed mediators b. Antibodies binding to soluble antigens that were re leased into body fluids and the immune complexes being deposited in the tissues c. Lymphokine -producing Th1 cells directly at tacking and destroying cellular targets d. Antibodies bin ding to the antigen on the cell surface ANSWER : C Type I, II, and III hypersensitivity reactions are mediated by antibody, type IV reactions are mediated by T lymphocytes and do not involve antibody. Type IV mechanisms occur through either Tc cells or lymphok ine-producing Th1 cells. Tc cells directly attack and destroy cellular targets.

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