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Lecture notes Cell Regulation lecture 2
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First set of lecture notes from a second year module called Cell regulation and cancer covering signal muscle contraction . Useful for anyone studying biochemistry or a related life science course, and also those studying A-Level Biology.

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  • April 23, 2021
  • 4
  • 2020/2021
  • Lecture notes
  • Joanna richardson
  • All classes

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Cell Regulation and Cancer Review Questions L2 – Signal for Muscle Contraction



Questions Answers
Where is acetylcholine synthesised? Cytoplasm of the pre-synaptic terminal
Where do vesicles release acetylcholine and what is the Into the synaptic gap, 1-2 milliseconds
half-life?
Which enzyme hydrolyses acetylcholine? Acetylcholinesterase
Which receptors do acetylcholine bind to in muscle Nicotinic Acetylcholine (ACh) receptors
cells?
What type of receptor is the nicotinic ACh receptor? Ionotropic
What is an ionotropic receptor? A receptor directly linked to an ion channel
What is a metabotropic receptor? A receptor which uses second messengers
Two main classes of ACh receptor? 1. Nicotinic = selectively activated by nicotine
2. Muscarinic = activated by muscarine
What type of ion channel is the nicotinic ACh receptor? Membrane-spanning ion channel
How many subunits in a nicotinic ACh receptor and how Five subunits: two alpha, one of each beta, gamma and
many of each type? delta
Which subunits of the nicotinic ACh receptor binds Alpha subunits
acetylcholine?




Which type of domains and how many do nicotinic ACh 4 helical transmembrane domains (M1-M4)
receptor subunits have?




Which domains form the wall of the nicotinic ACh The amphipathic M2 helices, other domains are
receptor channel? hydrophobic only




Why do hydrophilic residues line the channel of They are exposed to an aqueous environment and want

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